SCHEMBL27286282

SCHEMBL27286282

CC(=O)c1cnn(Cc2ccc(F)cc2C(F)(F)F)c1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 3/20 0.47
HDAC3 O15379 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC2 Q92769 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
AR P10275 1/20 0.44
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43
MAPT P10636 1/20 0.43
MAPK1 P28482 1/20 0.43
HTT P42858 1/20 0.43
IDO1 P14902 2/20 0.42
P2RX7 Q99572 7/20 0.41
SCD5 Q86SK9 1/20 0.41
NTRK1 P04629 1/20 0.41
ACHE P22303 1/20 0.40
KIF11 P52732 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30755311 0.89 HDAC3 (0.47) KLKB1HDAC3HDAC1HDAC2HDAC6
SCHEMBL27378742 0.89 HDAC3 (0.47) KLKB1HDAC3HDAC1HDAC2HDAC6
SCHEMBL27373753 0.85 GRM2 (0.49) KLKB1HDAC3HDAC1HDAC2HDAC6
SCHEMBL27286280 0.84 MAOA (0.49) KLKB1HDAC3HDAC1HDAC2HDAC6
SCHEMBL27373751 0.80 P2RX7 (0.41) KLKB1HDAC3HDAC1HDAC2HDAC6
SCHEMBL21523836 0.79 SCD5 (0.50) KLKB1SCD5NTRK1
SCHEMBL27364061 0.78 ADORA2B (0.47) KLKB1ARALDH1A1LMNAMAPT
Hydrochloric Acid SCHEMBL28532079 0.77 SCD5 (0.43) KLKB1HDAC3HDAC1HDAC2HDAC6
SCHEMBL27286277 0.76 AKR1C3 (0.40) ARALDH1A1MAPTACHE
SCHEMBL752774 0.76 LMNA (0.61) KLKB1ALDH1A1LMNAMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024026486-A2 CDK2 INHIBITORS AND METHODS OF USING THE SAME CEDILLA THERAPEUTICS, INC. (US) 2024-02-01 WO disclosed
WO-2024026484-A2 CDK2 INHIBITORS AND METHODS OF USING THE SAME CEDILLA THERAPEUTICS, INC. (US) 2024-02-01 WO disclosed
WO-2024026483-A2 CDK2 INHIBITORS AND METHODS OF USING THE SAME CEDILLA THERAPEUTICS, INC. (US) 2024-02-01 WO disclosed