SCHEMBL272966

SCHEMBL272966

Ic1cnn(Cc2ccccc2)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.62
CREBBP Q92793 4/20 0.48
CYP19A1 P11511 4/20 0.47
ADORA2A P29274 1/20 0.46
ADORA1 P30542 1/20 0.46
POLB P06746 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
HDAC3 O15379 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
NCOR2 Q9Y618 1/20 0.43
PSD A5PKW4 1/20 0.43
HSD17B10 Q99714 1/20 0.42
SIGMAR1 Q99720 1/20 0.42
PIK3CD O00329 1/20 0.42
PIK3CA P42336 1/20 0.42
PIK3CB P42338 1/20 0.42
PI4KA P42356 1/20 0.42
PIK3CG P48736 1/20 0.42
PI4KB Q9UBF8 1/20 0.42
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12068737 0.84 L3MBTL1 (0.56) L3MBTL1TDP1
SCHEMBL28393209 0.83 L3MBTL1 (0.47) L3MBTL1HDAC8HSD17B10LMNAMAPT
SCHEMBL17397329 0.80 L3MBTL1 (0.50) L3MBTL1ADORA2AADORA1HSD17B10
SCHEMBL6264956 0.78 L3MBTL1 (0.65) L3MBTL1CREBBPCYP19A1ADORA2AADORA1
SCHEMBL13075646 0.78 L3MBTL1 (0.59) L3MBTL1CREBBPCYP19A1ADORA2AADORA1
SCHEMBL671859 0.78 L3MBTL1 (0.50) L3MBTL1CYP19A1ADORA2AADORA1SIGMAR1
SCHEMBL28419208 0.78 CYP19A1 (0.54) CYP19A1
SCHEMBL3518605 0.78 HSP90AA1 (0.46) L3MBTL1POLBHSD17B10LMNAMAPT
SCHEMBL10283891 0.77 L3MBTL1 (0.62) L3MBTL1CREBBPCYP19A1ADORA2AADORA1
SCHEMBL2413457 0.77 L3MBTL1 (0.62) L3MBTL1CREBBPCYP19A1ADORA2AADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 202 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9139546-B2 Tri-aryl/heteroaromatic cannabinoids and use thereof THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2015-09-22 US claimed
US-20110207748-A1 Tri-Aryl/Heteroaromatic Cannabinoids and Use Thereof THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2011-08-25 US claimed
US-7888365-B2 Tri-aryl/heteroaromatic cannabinoids and use thereof THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2011-02-15 US claimed
CN-101668425-A Tri-aryl/heteroaroaromatic cannabinoids and use thereof UNIV TENNESSEE RES FOUNDATION 2010-03-10 CN claimed
EP-2131655-A2 TRI-ARYL/HETEROAROMATIC CANNABINOIDS AND USE THEREOF The University of Tennessee Research Foundation (US) 2009-12-16 EP claimed
US-20080234293-A1 Tri-aryl/heteroaromatic cannabinoids and use thereof THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2008-09-25 US claimed
WO-2008109027-A2 TRI-ARYL/HETEROAROAROMATIC CANNABINOIDS AND USE THEREOF UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, THE (US) 2008-09-12 WO claimed
US-20260008758-A1 LINEAR DIPEPTIDYL PEPTIDASE 1 INHIBITORS AND USES THEREOF INSMED INCORPORATED 2026-01-08 US disclosed
US-12486253-B2 Therapeutics for the degradation of mutant BRAF C4 THERAPEUTICS, INC. (US) 2025-12-02 US disclosed
WO-2025129116-A1 COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 C4 THERAPEUTICS, INC. (US) 2025-06-19 WO disclosed
EP-4539849-A1 COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 C4 Therapeutics, Inc. (US) 2025-04-23 EP disclosed
US-20250121070-A1 COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 C4 THERAPEUTICS, INC. (US) 2025-04-17 US disclosed
US-20250115580-A1 THERAPEUTICS FOR THE DEGRADATION OF MUTANT BRAF C4 THERAPEUTICS, INC. (US) 2025-04-10 US disclosed
WO-2004011010-A1 MYOCARDIAL PERFUSION IMAGING USING A2A RECEPTOR AGONISTS CV THERAPEUTICS, INC. (US) 2004-02-05 WO disclosed
EP-1192169-B1 C-PYRAZOLE A2A RECEPTOR AGONISTS CV THERAPEUTICS INC (US) 2003-05-14 EP disclosed
CN-1358189-A C-2A pyrazole A2A receptor agonists CV THERAPEUTICS INC (US) 2002-07-10 CN disclosed
EP-1192169-A2 C-PYRAZOLE A2A RECEPTOR AGONISTS CV THERAPEUTICS, INC. (US) 2002-04-03 EP disclosed
US-20010018428-A1 C-pyrazole A2A receptor agonists CV THERAPEUTICS, INC. 2001-08-30 US disclosed
US-6214807-B1 IMAGES AND CARDIOVASCULAR DISORDERS CV THERAPEUTICS, INC. 2001-04-10 US disclosed
WO-2000078778-A2 C-PYRAZOLE A2A RECEPTOR AGONISTS CV THERAPEUTICS, INC. (US) 2000-12-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12486253-B2 Therapeutics for the degradation of mutant BRAF BRAF, NRAS, KRAS L3MBTL1 595/4885CREBBP 363/4885CYP19A1 4459/4885
US-20010018428-A1 C-pyrazole A2A receptor agonists ADORA2A, ADORA3, ADORA1 L3MBTL1 4669/4885CREBBP 2300/4885CYP19A1 2077/4885
US-20250121070-A1 COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 SMARCA2, SMARCE1, SMARCA1 L3MBTL1 3239/4885CREBBP 1433/4885CYP19A1 2115/4885
US-20080234293-A1 Tri-aryl/heteroaromatic cannabinoids and use thereof CNR1, CNR2, OPRM1 L3MBTL1 4553/4885CREBBP 936/4885CYP19A1 395/4885
US-20110207748-A1 Tri-Aryl/Heteroaromatic Cannabinoids and Use Thereof CNR1, CNR2, OPRM1 L3MBTL1 4553/4885CREBBP 936/4885CYP19A1 395/4885
US-20260008758-A1 LINEAR DIPEPTIDYL PEPTIDASE 1 INHIBITORS AND USES THEREOF DPP3, DPP7, DPP9 L3MBTL1 674/4885CREBBP 4399/4885CYP19A1 2182/4885
US-20250115580-A1 THERAPEUTICS FOR THE DEGRADATION OF MUTANT BRAF BRAF, NRAS, KRAS L3MBTL1 595/4885CREBBP 363/4885CYP19A1 4459/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.