Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | VNN1 | O95497 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31473371 | 1.00 | PDE10A (0.39) | PDE10AKLKB1KLK1TRPV1GAA | |
| SCHEMBL7252180 | 0.73 | KMT2A (0.48) | KMT2AMT-CO2ALDH1A1ESR1ESR2 | |
| SCHEMBL31473467 | 0.71 | HCAR3 (0.41) | PDE10AKLKB1KLK1TRPV1KMT2A | |
| SCHEMBL27299149 | 0.71 | HCAR3 (0.41) | PDE10AKLKB1KLK1TRPV1KMT2A | |
| SCHEMBL27299043 | 0.71 | PDE4A (0.35) | PDE10AAOC3 | |
| SCHEMBL22387918 | 0.71 | PDE10A (0.37) | PDE10A | |
| SCHEMBL14658669 | 0.70 | TRPV1 (0.55) | TRPV1MT-CO2HCAR3AOC3 | |
| SCHEMBL14032514 | 0.70 | L3MBTL1 (0.46) | KMT2AMT-CO2ALDH1A1 | |
| SCHEMBL14660039 | 0.69 | DGAT1 (0.47) | TRPV1HCAR3 | |
| SCHEMBL31473426 | 0.69 | HCAR3 (0.47) | PDE10AKLKB1KLK1HCAR3GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024029489-A1 | KIT INHIBITORS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | MODULUS DISCOVERY, INC. (JP) | 2024-02-08 | — | — | WO | disclosed |