Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | CMA1 | P23946 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MIF | P14174 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL95457 | 0.89 | TAAR1 (0.62) | TAAR1CYP3A4CYP1A2MAPTCALM1 | |
| SCHEMBL315045 | 0.88 | TAAR1 (0.52) | TAAR1CYP3A4CYP1A2MAPTCALM1 | |
| SCHEMBL108087 | 0.87 | TAAR1 (0.77) | TAAR1CYP3A4CYP1A2MAPTCALM1 | |
| SCHEMBL3030397 | 0.87 | TAAR1 (0.61) | TAAR1CYP3A4CYP1A2MAPTCALM1 | |
| SCHEMBL7425426 | 0.85 | TAAR1 (0.59) | TAAR1CYP3A4CYP1A2MAPTCALM1 | |
| SCHEMBL3023636 | 0.85 | TAAR1 (0.49) | TAAR1CYP3A4CYP1A2MAPTCALM1 | |
| SCHEMBL699637 | 0.83 | CYP3A4 (0.63) | TAAR1CYP3A4CYP1A2MAPTCALM1 | |
| SCHEMBL108050 | 0.83 | CALM1 (0.72) | TAAR1CYP3A4CYP1A2MAPTCALM1 | |
| SCHEMBL11240060 | 0.82 | CYP3A4 (0.64) | TAAR1CYP3A4CYP1A2MAPTCALM1 | |
| SCHEMBL28886939 | 0.82 | CYP3A4 (0.61) | TAAR1CYP3A4CYP1A2MAPTCALM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112812133-B | Alpha, alpha-difluoroallyl organometallic compound and preparation method and application thereof | 南京工业大学 | 2022-03-11 | — | — | CN | claimed |
| CN-112812133-A | Alpha, alpha-difluoroallyl organometallic compound and preparation method and application thereof | 南京工业大学 | 2021-05-18 | — | — | CN | claimed |
| CN-110003042-A | α, α -difluoroallyl aromatic hydrocarbon compound and preparation method thereof | 南京工业大学 | 2019-07-12 | — | — | CN | claimed |
| CN-103459382-A | Heterocyclic compounds for the inhibition of pask | BIOENERGENIX LLC | 2013-12-18 | — | — | CN | claimed |
| EP-1716160-B1 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-29 | — | — | EP | claimed |
| US-20090036409-A1 | Novel inhibitors of chymase | HAWKINS MICHAEL J | 2009-02-05 | — | — | US | claimed |
| US-7459444-B2 | Inhibitors of chymase | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-02 | — | — | US | claimed |
| US-20080076817-A1 | Small Molecule Rotamase Enzyme Inhibitors | HAMILTON GREGORY S | 2008-03-27 | — | — | US | claimed |
| JP-2007518807-A | — | — | 2007-07-12 | — | — | JP | claimed |
| EP-1716160-A2 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-11-02 | — | — | EP | claimed |
| EP-1011650-A1 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | Amgen Inc., (US) | 2000-06-28 | — | — | EP | claimed |
| EP-0998263-A1 | PYRROLIDINE DERIVATIVE HAIR GROWTH COMPOSITIONS AND USES | GUILFORD PHARMACEUTICALS INC. (US) | 2000-05-10 | — | — | EP | claimed |
| EP-0992492-A1 | Small molecule inhibitors of rotamase enzyme activity | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-12 | — | — | EP | claimed |
| WO-1999014998-A2 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | AMGEN INC. (US) | 1999-04-01 | — | — | WO | claimed |
| WO-1998055091-A1 | PYRROLIDINE DERIVATIVE HAIR GROWTH COMPOSITIONS AND USES | GUILFORD PHARMACEUTICALS INC. (US) | 1998-12-10 | — | — | WO | claimed |
| EP-0769006-A4 | — | GUILFORD PHARM INC (US) | 1997-05-28 | — | — | EP | claimed |
| EP-0769006-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1997-04-23 | — | — | EP | claimed |
| US-5614547-A | Small molecule inhibitors of rotamase enzyme | GUILFORD PHARMACEUTICALS INC. (US) | 1997-03-25 | — | — | US | claimed |
| WO-1996040633-A9 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | — | 1997-02-27 | — | — | WO | claimed |
| WO-1996040633-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1996-12-19 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036409-A1 | Novel inhibitors of chymase | CMA1, SERPINB1, TPSAB1 | TAAR1 1849/4885CYP3A4 939/4885CYP1A2 1199/4885 |
| US-20080076817-A1 | Small Molecule Rotamase Enzyme Inhibitors | FKBP8, FKBP1A, FKBP2 | TAAR1 4509/4885CYP3A4 3508/4885CYP1A2 3667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.