SCHEMBL27318591

SCHEMBL27318591

[CH2]c1cccc(N(CCC)c2ccccc2)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 5/20 0.40
MTNR1B P49286 5/20 0.40
DHFR P00374 2/20 0.38
RXRA P19793 1/20 0.37
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35
SLC6A3 Q01959 1/20 0.35
CRHR1 P34998 1/20 0.35
TP53 P04637 1/20 0.35
KCNH2 Q12809 1/20 0.35
MAPT P10636 1/20 0.35
CRHBP P24387 1/20 0.35
CRHR2 Q13324 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
NR3C2 P08235 1/20 0.35
KCNA5 P22460 2/20 0.35
KCNN4 O15554 1/20 0.35
MEN1 O00255 1/20 0.35
CASP1 P29466 1/20 0.35
BRCA1 P38398 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL158097 0.82 MTNR1A (0.48) MTNR1AMTNR1BDHFRSLC6A2SLC6A4
Hydrochloric Acid SCHEMBL10684893 0.80 MTNR1A (0.47) MTNR1AMTNR1BDHFRTP53KCNH2
Ammonia Solution, Strong SCHEMBL4595141 0.80 MTNR1A (0.47) MTNR1AMTNR1BDHFRSLC6A2SLC6A4
SCHEMBL7153293 0.80 MTNR1A (0.47) MTNR1AMTNR1BDHFRRXRASLC6A2
SCHEMBL7335494 0.79 ALDH1A1 (0.41) CRHR1MAPTKCNA5KCNN4DRD2
SCHEMBL10653515 0.79 SIGMAR1 (0.47) MTNR1AMTNR1BTP53KCNH2DRD2
SCHEMBL18604654 0.79 MAOA (0.44) MTNR1AMTNR1BDHFRRXRATP53
SCHEMBL29825453 0.79 MAOA (0.44) MTNR1AMTNR1BDHFRRXRATP53
SCHEMBL28162933 0.76 ALDH1A1 (0.32) TP53MAPTKCNA5KCNN4DRD2
SCHEMBL22422827 0.75 RXRA (0.44) MTNR1AMTNR1BDHFRRXRAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1030415-A Saturated heterocycle carboxamide derivatives and its preparation method YAMANOUCHI PHARMA CO LTD (JP) 1989-01-18 CN disclosed