Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SDCBP | O00560 | 3/20 | 0.41 |
| ▸ | SDC2 | P34741 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21622035 | 0.91 | NPC1 (0.42) | NPC1RAB9ASDCBPSDC2ALOX15 | |
| SCHEMBL27320692 | 0.91 | NPC1 (0.42) | NPC1RAB9ASDCBPSDC2ALOX15 | |
| SCHEMBL24421373 | 0.90 | SDCBP (0.42) | NPC1RAB9ASDCBPSDC2ALOX15 | |
| SCHEMBL24294314 | 0.88 | THRB (0.43) | ALOX15KDM4ETHRBGAAPOLB | |
| SCHEMBL24294534 | 0.88 | THRB (0.43) | ALOX15KDM4ETHRBGAAPOLB | |
| SCHEMBL23729693 | 0.83 | THRB (0.37) | ALOX15KDM4ETHRBGAAPOLB | |
| SCHEMBL25032020 | 0.82 | ALOX15 (0.40) | SDCBPSDC2ALOX15KDM4ETHRB | |
| SCHEMBL25993234 | 0.82 | THRB (0.44) | ALOX15KDM4ETHRBGAAPOLB | |
| SCHEMBL26847910 | 0.82 | ITGB3 (0.49) | ALOX15KDM4ETHRBGAAPOLB | |
| SCHEMBL24421564 | 0.81 | SDCBP (0.42) | NPC1RAB9ASDCBPSDC2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006881-A1 | WEE1 DEGRADING COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-01-04 | — | — | WO | disclosed |