Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAP3K12 | Q12852 | 6/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2767593 | 0.66 | CTNNB1 (0.35) | ALDH1A1HPGDNPC1TP53MAPT | |
| SCHEMBL27201572 | 0.65 | HSD11B1 (0.64) | ALDH1A1HSD11B1 | |
| SCHEMBL174319 | 0.64 | L3MBTL1 (0.36) | ALDH1A1HPGDPROKR1NPC1RAB9A | |
| SCHEMBL2789326 | 0.62 | AKR1C3 (0.49) | HPGDMAPTSMN1; SMN2 | |
| SCHEMBL3312540 | 0.62 | ALDH1A1 (0.62) | ALDH1A1HPGDHSD11B1PROKR1NPC1 | |
| SCHEMBL28080532 | 0.62 | JAK3 (0.52) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL23580775 | 0.62 | BTK (0.35) | ALDH1A1HPGD | |
| SCHEMBL23580773 | 0.62 | BTK (0.35) | ALDH1A1HPGD | |
| SCHEMBL2514536 | 0.62 | HTR2B (0.61) | SMN1; SMN2 | |
| SCHEMBL2520100 | 0.62 | HTR2B (0.61) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632898-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | Biogen Idec MA Inc. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058645-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2012-05-03 | — | — | WO | disclosed |