SCHEMBL273303

SCHEMBL273303

O=C1NCCCCC1NCc1ccn(Cc2ccccc2)c(=O)c1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 12/20 1.00
VEGFA P15692 11/20 1.00
ALDH1A1 P00352 3/20 0.41
CNR1 P21554 2/20 0.41
CNR2 P34972 2/20 0.41
KDM4E B2RXH2 4/20 0.40
HPGD P15428 1/20 0.39
TP53 P04637 1/20 0.39
CYP2D6 P10635 1/20 0.39
HTT P42858 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12598838 0.90 EGLN1 (0.82) EGLN1VEGFAALDH1A1CNR1CNR2
SCHEMBL30274325 0.82 EGLN1 (0.69) EGLN1VEGFAALDH1A1CNR1CNR2
SCHEMBL278141 0.82 EGLN1 (0.79) EGLN1VEGFAALDH1A1CNR1CNR2
SCHEMBL19478702 0.81 EGLN1 (0.68) EGLN1VEGFAALDH1A1CNR1CNR2
SCHEMBL27636343 0.79 EGLN1 (0.65) EGLN1VEGFAALDH1A1CNR1CNR2
SCHEMBL7095007 0.77 VEGFA (0.61) EGLN1VEGFAALDH1A1KDM4EHTT
SCHEMBL271477 0.75 VEGFA (0.76) EGLN1VEGFA
SCHEMBL272935 0.75 EGLN1 (1.00) EGLN1VEGFACNR1CNR2KDM4E
SCHEMBL16789163 0.74 EGLN1 (0.78) EGLN1VEGFAALDH1A1CNR1CNR2
SCHEMBL19478697 0.74 EGLN1 (0.78) EGLN1VEGFAKDM4ETP53CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2496082-B1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS INC (US) 2016-10-12 EP claimed
US-20150157617-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2015-06-11 US claimed
US-8999971-B2 Methods for increasing the stabilization of hypoxia inducible factor-1 alpha AERPIO THERAPEUTICS INC. (US) 2015-04-07 US claimed
US-20140364419-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2014-12-11 US claimed
US-20130158010-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS INC. (US) 2013-06-20 US claimed
US-20110111058-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2011-05-12 US claimed
CN-116018136-A Hypoxia-inducible factor prolyl hydroxylase inhibitors for the treatment of aging-related disorders 百爱及生物医药公司 2023-04-25 CN disclosed
US-20220185778-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS INC (US) 2022-06-16 US disclosed
US-20220185778-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS INC (US) 2022-06-16 US disclosed
US-20210353612-A1 HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITORS FOR TREATING AGING-RELATED CONDITIONS BioAge Labs, Inc. 2021-11-18 US disclosed
EP-3698794-A1 COMPOSITIONS AND METHODS FOR TREATING COLITIS Aerpio Therapeutics, Inc. (US) 2020-08-26 EP disclosed
US-10562854-B2 Prolyl hydroxylase inhibitors AERPIO THERAPEUTICS, INC. (US) 2020-02-18 US disclosed
US-10562854-B2 Prolyl hydroxylase inhibitors AERPIO THERAPEUTICS, INC. (US) 2020-02-18 US disclosed
US-20110111058-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2011-05-12 US disclosed
WO-2011057115-A1 PROLYL HYDROXYLASE INHIBITORS AKEBIA THERAPEUTICS INC. (US) 2011-05-12 WO disclosed
WO-2011057112-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AKEBIA THERAPEUTICS INC. (US) 2011-05-12 WO disclosed
WO-2011057121-A1 COMPOSITIONS AND METHODS FOR TREATING COLITIS AKEBIA THERAPEUTICS INC. (US) 2011-05-12 WO disclosed
US-20110112055-A1 COMPOSITIONS AND METHODS FOR TREATING COLITIS AERPIO THERAPEUTICS LLC 2011-05-12 US disclosed
US-20110112055-A1 COMPOSITIONS AND METHODS FOR TREATING COLITIS AERPIO THERAPEUTICS LLC 2011-05-12 US disclosed
US-20110111058-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2011-05-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150157617-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 EGLN1 8/4885VEGFA 20/4885ALDH1A1 505/4885
US-20210353612-A1 HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITORS FOR TREATING AGING-RELATED CONDITIONS HIF1AN, HIF1A, P4HA1 EGLN1 11/4885VEGFA 384/4885ALDH1A1 374/4885
US-20110112055-A1 COMPOSITIONS AND METHODS FOR TREATING COLITIS ALPI, SI, SLC10A2 EGLN1 2861/4885VEGFA 4546/4885ALDH1A1 780/4885
US-20220185778-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, HIF1A, EGLN2 EGLN1 5/4885VEGFA 551/4885ALDH1A1 652/4885
US-20110111058-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 EGLN1 8/4885VEGFA 20/4885ALDH1A1 505/4885
US-20140364419-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 EGLN1 8/4885VEGFA 20/4885ALDH1A1 505/4885
US-20130158010-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 EGLN1 8/4885VEGFA 20/4885ALDH1A1 505/4885
US-10562854-B2 Prolyl hydroxylase inhibitors HIF1AN, HIF1A, EGLN2 EGLN1 5/4885VEGFA 551/4885ALDH1A1 652/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.