SCHEMBL2733743

SCHEMBL2733743

c1ccc(-c2cc(-c3ccccn3)c(-c3ccccc3)c3c2-c2cccc4cccc-3c24)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 3/20 0.41
SMN1; SMN2 Q16637 5/20 0.39
KDM4E B2RXH2 5/20 0.39
TP53 P04637 4/20 0.39
MAPK1 P28482 3/20 0.39
CCR1 P32246 3/20 0.39
CCR5 P51681 3/20 0.39
CCR8 P51685 3/20 0.39
LMNA P02545 3/20 0.39
TDP1 Q9NUW8 2/20 0.39
ALPL P05186 1/20 0.39
HSP90AA1 P07900 1/20 0.39
ALPI P09923 1/20 0.39
ALPG P10696 1/20 0.39
ALOX15 P16050 1/20 0.39
HTT P42858 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ALDH1A1 P00352 3/20 0.38
TGFBR1 P36897 1/20 0.38
GAA P10253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16658479 0.93 GRM5 (0.43) GRM5SMN1; SMN2KDM4ETP53MAPK1
SCHEMBL16658502 0.93 GRM5 (0.41) GRM5SMN1; SMN2KDM4ETP53MAPK1
SCHEMBL16658498 0.92 GRM5 (0.40) GRM5SMN1; SMN2KDM4ETP53MAPK1
SCHEMBL17014605 0.89 CCR1 (0.42) GRM5SMN1; SMN2KDM4ETP53MAPK1
SCHEMBL17014604 0.89 CCR1 (0.42) GRM5SMN1; SMN2KDM4ETP53MAPK1
SCHEMBL2734770 0.85 SMN1; SMN2 (0.46) GRM5SMN1; SMN2KDM4ETP53MAPK1
SCHEMBL2158220 0.85 ALDH1A1 (0.47) SMN1; SMN2KDM4ETP53MAPK1L3MBTL1
SCHEMBL2733765 0.84 HTR2C (0.41) GRM5TP53MAPK1L3MBTL1ALDH1A1
SCHEMBL17014583 0.84 PIK3CA (0.40) GRM5KDM4EMAPK1CCR1CCR5
SCHEMBL4124154 0.83 TGFBR1 (0.47) GRM5SMN1; SMN2KDM4ETP53MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8088500-B2 OLED device with fluoranthene electron injection materials GLOBAL OLED TECHNOLOGY LLC (US) 2012-01-03 US disclosed
US-8088500-B2 OLED device with fluoranthene electron injection materials GLOBAL OLED TECHNOLOGY LLC (US) 2012-01-03 US disclosed
US-20100117520-A1 OLED DEVICE WITH FLUORANTHENE ELECTRON INJECTION MATERIALS GLOBAL OLED TECHNOLOGY LLC 2010-05-13 US disclosed
US-20100117520-A1 OLED DEVICE WITH FLUORANTHENE ELECTRON INJECTION MATERIALS GLOBAL OLED TECHNOLOGY LLC 2010-05-13 US disclosed