Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ICMT | O60725 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3353333 | 0.82 | HTR6 (0.46) | HTR2AHTR2CHTR2BLMNAHTT | |
| SCHEMBL13888165 | 0.81 | CDK2 (0.44) | HTR2ALMNAHTTMAPTGPR84 | |
| SCHEMBL9919108 | 0.80 | BRD9 (0.48) | MAPTICMTSLC6A4TDP1 | |
| SCHEMBL20910199 | 0.80 | HTR2A (0.42) | HTR2AHTR2CHTR2BLMNAHTT | |
| SCHEMBL13537350 | 0.78 | HTR2A (0.41) | HTR2AHTR2CHTR2BLMNAHTT | |
| SCHEMBL24144470 | 0.78 | CDK2 (0.45) | HTR2ALMNAHTTHPGDMAPT | |
| SCHEMBL10261961 | 0.77 | GPR84 (0.67) | HTR2AHTR2CHTR2BLMNAHTT | |
| SCHEMBL18404868 | 0.77 | HTR2A (0.63) | HTR2AHTR2CGPR84CDK2HTR6 | |
| SCHEMBL1094415 | 0.77 | GPR84 (0.43) | HTR2ALMNAHTTHPGDMAPT | |
| SCHEMBL8434401 | 0.75 | IMPDH2 (0.39) | HTR2ALMNAHTTHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006403-A2 | SELECTIVE HISTONE DEACETYLASE 8 (HDAC8) DEGRADERS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2024-01-04 | — | — | WO | disclosed |