Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 5/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.52 |
| ▸ | AKT1 | P31749 | 4/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.52 |
| ▸ | PRKG2 | Q13237 | 4/20 | 0.52 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.52 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.52 |
| ▸ | GSK3A | P49840 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.52 |
| ▸ | CDK1 | P06493 | 3/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1135419 | 0.84 | EPHX2 (0.54) | LMNAALDH1A1KMT2AMEN1EPHX2 | |
| SCHEMBL11626488 | 0.79 | ALDH1A1 (0.74) | LMNAALDH1A1KMT2AMEN1GSK3B | |
| SCHEMBL250886 | 0.77 | TACR3 (0.49) | LMNAALDH1A1KMT2AMEN1TACR3 | |
| SCHEMBL16989173 | 0.77 | TACR3 (0.49) | LMNAKMT2AMEN1MAPK1TACR3 | |
| SCHEMBL16989172 | 0.77 | TACR3 (0.49) | LMNAKMT2AMEN1MAPK1TACR3 | |
| SCHEMBL1568720 | 0.76 | ROCK2 (0.83) | LMNAALDH1A1KMT2AMEN1GSK3B | |
| SCHEMBL2408678 | 0.75 | HPGDS (0.54) | LMNAALDH1A1TACR3PDE2ASMN1; SMN2 | |
| SCHEMBL2442820 | 0.75 | HPGDS (0.54) | LMNAALDH1A1TACR3PDE2ASMN1; SMN2 | |
| SCHEMBL19158873 | 0.75 | TACR3 (0.47) | LMNAALDH1A1KMT2AMAPK1TACR3 | |
| SCHEMBL11249593 | 0.75 | ALDH1A1 (0.57) | LMNAALDH1A1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |