SCHEMBL27357732

SCHEMBL27357732

O=C(NCCCC[C@H](NC(=O)OC12CC3CC(C1)C(NCC(=O)N1Cc4ccccc4C1)(C3)C2)C(=O)O)OCc1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ DPP8 Q6V1X1 16/20 0.55
▸ DPP9 Q86TI2 15/20 0.55
▸ GLMN Q92990 2/20 0.48
▸ DPP7 Q9UHL4 1/20 0.47
▸ TGM2 P21980 1/20 0.47
▸ FOLH1 Q04609 1/20 0.44
▸ ACE P12821 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30685134 0.90 DPP8 (0.69) DPP8DPP9GLMN
SCHEMBL27356105 0.90 DPP8 (0.69) DPP8DPP9GLMN
SCHEMBL27357677 0.81 DPP8 (0.77) DPP8DPP9GLMN
SCHEMBL27356099 0.81 DPP8 (0.53) DPP8DPP9GLMNDPP7TGM2
SCHEMBL30685198 0.79 DPP8 (0.59) DPP8DPP9GLMN
SCHEMBL27356370 0.79 DPP8 (0.59) DPP8DPP9GLMN
SCHEMBL27356571 0.73 SIRT2 (0.50) DPP8DPP7TGM2FOLH1
SCHEMBL30685077 0.71 DPP8 (1.00) DPP8DPP9GLMN
SCHEMBL27356164 0.71 DPP8 (1.00) DPP8DPP9GLMN
SCHEMBL806151 0.70 FOLH1 (0.78) TGM2FOLH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023233024-A1 DPP9 BINDING COMPOUNDS UNIVERSITEIT ANTWERPEN (BE) 2023-12-07 — — WO disclosed
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