Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.37 |
| ▸ | BRAF | P15056 | 3/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27360684 | 0.92 | CYP3A4 (0.34) | BRAFMAPK1KCNH2ELANEXIAP | |
| SCHEMBL27360587 | 0.92 | PTGES (0.35) | BRAFMAPK1KCNH2ELANEXIAP | |
| SCHEMBL27360586 | 0.90 | DPP4 (0.40) | BRAFMAPK1KCNH2ELANEXIAP | |
| SCHEMBL27360675 | 0.89 | ELANE (0.38) | KCNH2ELANEXIAPMLX | |
| SCHEMBL27360670 | 0.88 | ELANE (0.36) | MAPK1KCNH2ELANEXIAPMLX | |
| SCHEMBL27360583 | 0.88 | DPP4 (0.37) | MAPK1KCNH2ELANEXIAPMLX | |
| SCHEMBL27360584 | 0.87 | ELANE (0.35) | MAPK1DYRK1AKCNH2ELANEXIAP | |
| SCHEMBL26847747 | 0.77 | VHL (0.51) | — | |
| SCHEMBL27360352 | 0.75 | XIAP (0.39) | ROCK2BRAFROCK1MAPK13RPS6KA5 | |
| SCHEMBL26786350 | 0.72 | VHL (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024040080-A1 | KRAS INHIBITOR CONJUGATES | ERASCA, INC. (US) | 2024-02-22 | — | — | WO | disclosed |