Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP4 | P49662 | 1/20 | 0.36 |
| ▸ | CASP5 | P51878 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15759139 | 0.87 | CHRM5 (0.46) | ACHEGPR119CHRM4KCNH2THRB | |
| SCHEMBL12523970 | 0.86 | GPR119 (0.50) | ACHEGPR119ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL27363067 | 0.85 | GPR119 (0.41) | GPR119ALDH1A1CHRM4KCNH2CASP1 | |
| SCHEMBL27363461 | 0.85 | KCNH2 (0.42) | GPR119ALDH1A1CHRM4KCNH2LMNA | |
| SCHEMBL27363070 | 0.85 | AOC3 (0.46) | GPR119CHRM4KCNH2 | |
| SCHEMBL26157326 | 0.84 | ACHE (0.41) | ACHEALDH1A1TSHRL3MBTL1CHRM4 | |
| SCHEMBL27363464 | 0.82 | CASP1 (0.42) | GPR119ALDH1A1KCNH2LMNACASP1 | |
| SCHEMBL27362982 | 0.82 | MAPT (0.51) | ACHEGPR119ALDH1A1TSHRCHRM4 | |
| SCHEMBL26157300 | 0.81 | ACHE (0.41) | ACHEALDH1A1TSHRL3MBTL1CHRM4 | |
| SCHEMBL27366889 | 0.78 | CASP1 (0.41) | GPR119ALDH1A1KCNH2CASP1CASP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |