Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP4 | P49662 | 1/20 | 0.41 |
| ▸ | CASP5 | P51878 | 1/20 | 0.41 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27363464 | 0.84 | CASP1 (0.42) | CASP1CASP4CASP5TRPC5CACNA2D1 | |
| SCHEMBL27366890 | 0.82 | DRD2 (0.46) | CASP1CASP4CASP5CACNA2D1CACNA1B | |
| SCHEMBL27363067 | 0.81 | GPR119 (0.41) | CASP1CASP4CASP5CACNA2D1CACNA1B | |
| SCHEMBL27363461 | 0.81 | KCNH2 (0.42) | CASP1CASP4CASP5CACNA2D1CACNA1B | |
| SCHEMBL26157300 | 0.80 | ACHE (0.41) | CACNA2D1CACNA1BCACNB1TAAR1AXL | |
| SCHEMBL26157301 | 0.80 | DRD2 (0.40) | CASP1CASP4CASP5TRPC5CACNA2D1 | |
| SCHEMBL27364869 | 0.79 | DHFR (0.39) | CASP1CASP4CASP5GPR119DHFR | |
| SCHEMBL15759139 | 0.79 | CHRM5 (0.46) | CASP1CASP4CASP5TRPC5GPR119 | |
| SCHEMBL27368275 | 0.79 | TAAR1 (0.44) | CASP1TAAR1DHFRALDH1A1KDM4E | |
| SCHEMBL27366339 | 0.79 | PDE10A (0.47) | CACNA2D1CACNA1BCACNB1GPR119DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |