Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP4 | P49662 | 1/20 | 0.39 |
| ▸ | CASP5 | P51878 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27363461 | 0.97 | KCNH2 (0.42) | GPR119CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL27363464 | 0.97 | CASP1 (0.42) | GPR119CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL27363063 | 0.88 | KCNH2 (0.36) | GPR119CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL15759139 | 0.87 | CHRM5 (0.46) | GPR119KCNH2CASP1CASP4CASP5 | |
| SCHEMBL27362872 | 0.85 | ACHE (0.47) | GPR119KCNH2CASP1CASP4CASP5 | |
| SCHEMBL27362988 | 0.84 | KCNH2 (0.41) | CACNA2D1CACNA1BCACNB1CACNA1CKCNH2 | |
| SCHEMBL27363065 | 0.84 | MET (0.44) | ALDH1A1CYP1A2CYP3A4CYP2C9HSD17B10 | |
| SCHEMBL27364869 | 0.84 | DHFR (0.39) | GPR119CASP1CASP4CASP5HTR1A | |
| SCHEMBL27363062 | 0.82 | GPR119 (0.41) | GPR119KCNH2HRH4HTR3AHRH3 | |
| SCHEMBL27363157 | 0.82 | GPR119 (0.39) | GPR119KCNH2HTR1AHRH4HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |