Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL82021 | 0.89 | GPR119 (0.44) | DRD2DRD3GPR119KCNH2DHFR | |
| SCHEMBL12525108 | 0.84 | GPR119 (0.47) | GPR119KCNH2PTPN11MAPK1 | |
| SCHEMBL82297 | 0.83 | GPR119 (0.41) | GPR119KCNH2DHFROGATRPV6 | |
| SCHEMBL27363069 | 0.79 | SIGMAR1 (0.33) | DRD2DRD3KCNH2TRPV6HRH3 | |
| SCHEMBL14853335 | 0.76 | L3MBTL3 (0.50) | GPR119KCNH2HRH3ALDH1A1 | |
| SCHEMBL24018524 | 0.75 | GPR119 (0.39) | GPR119KCNH2DHFROGAALDH1A1 | |
| SCHEMBL12793873 | 0.75 | POLB (0.34) | DRD2DRD3HRH3MEN1ALDH1A1 | |
| SCHEMBL12793878 | 0.75 | POLB (0.34) | DRD2DRD3HRH3MEN1ALDH1A1 | |
| SCHEMBL15685757 | 0.75 | POLB (0.34) | DRD2DRD3HRH3MEN1ALDH1A1 | |
| SCHEMBL12490730 | 0.74 | OPRK1 (0.52) | GPR119KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |