Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 4/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 4/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27363631 | 0.79 | DRD2 (0.40) | TRPV6DRD2DRD3HRH3KCNH2 | |
| SCHEMBL82021 | 0.71 | GPR119 (0.44) | TRPV6DRD2DRD3HRH3KCNH2 | |
| SCHEMBL12525108 | 0.67 | GPR119 (0.47) | KCNH2 | |
| SCHEMBL82297 | 0.66 | GPR119 (0.41) | TRPV6HRH3KCNH2 | |
| SCHEMBL20463090 | 0.64 | HDAC6 (0.53) | SIGMAR1DRD2DRD3HRH3HDAC6 | |
| SCHEMBL27363160 | 0.62 | FGFR3 (0.37) | TRPV6HTR1AHRH3FGFR3KCNH2 | |
| SCHEMBL17972976 | 0.62 | DHFR (0.49) | SIGMAR1DRD2 | |
| SCHEMBL27363701 | 0.62 | HTR3A (0.45) | SIGMAR1HTR1AHDAC6 | |
| SCHEMBL27365699 | 0.62 | SIGMAR1 (0.53) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL20064017 | 0.61 | HRH4 (0.44) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |