Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20463090 | 0.91 | HDAC6 (0.53) | SIGMAR1HDAC6DRD2DRD1DRD3 | |
| SCHEMBL27365286 | 0.82 | DRD3 (0.50) | SIGMAR1HDAC6DRD2DRD1DRD3 | |
| SCHEMBL13103868 | 0.81 | DRD2 (0.71) | SIGMAR1DRD2DRD1DRD3DRD5 | |
| SCHEMBL26341182 | 0.80 | SIGMAR1 (0.45) | SIGMAR1HDAC6DRD2DRD1DRD3 | |
| SCHEMBL27363701 | 0.79 | HTR3A (0.45) | SIGMAR1HDAC6HTR1AALDH1A1CYP1A2 | |
| SCHEMBL17972976 | 0.79 | DHFR (0.49) | SIGMAR1DRD2GRM2 | |
| SCHEMBL23696422 | 0.79 | SIGMAR1 (0.45) | SIGMAR1HDAC6DRD2DRD1DRD3 | |
| SCHEMBL22856124 | 0.79 | SIGMAR1 (0.45) | SIGMAR1HDAC6DRD2DRD1DRD3 | |
| SCHEMBL24508284 | 0.78 | SIGMAR1 (0.44) | SIGMAR1HDAC6DRD2DRD1DRD3 | |
| SCHEMBL25730366 | 0.78 | SIGMAR1 (0.44) | SIGMAR1HDAC6DRD2DRD1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |