Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 4/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP4 | P49662 | 1/20 | 0.39 |
| ▸ | CASP5 | P51878 | 1/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3826430 | 0.90 | CASP1 (0.43) | PARP1CASP1CASP4CASP5OGA | |
| SCHEMBL3825095 | 0.86 | CASP1 (0.53) | PARP1CASP1CASP4CASP5OGA | |
| SCHEMBL27367621 | 0.83 | HRH3 (0.41) | PARP1CASP1CASP4CASP5OGA | |
| SCHEMBL30139760 | 0.78 | CACNA2D1 (0.43) | CACNA2D1CACNA1BCACNB1PARP1CASP1 | |
| SCHEMBL3066937 | 0.77 | BPTF (0.62) | BPTFCASP1CASP4CASP5OGA | |
| SCHEMBL27366890 | 0.75 | DRD2 (0.46) | BPTFCACNA2D1CACNA1BCACNB1PARP1 | |
| SCHEMBL27366886 | 0.74 | LTA4H (0.49) | CACNA2D1CACNA1BCACNB1DRD2DRD3 | |
| SCHEMBL20255203 | 0.74 | PDE10A (0.40) | BPTFOGA | |
| SCHEMBL23875271 | 0.73 | HPGDS (0.46) | CACNA2D1CACNA1BCACNB1PARP1DRD2 | |
| SCHEMBL5654761 | 0.72 | BPTF (0.56) | BPTFCASP1CASP4CASP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |