Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP2J2 | P51589 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27384649 | 0.85 | HTT (0.42) | SMN1; SMN2CYP2C9CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27384690 | 0.80 | BTK (0.40) | SMN1; SMN2CYP2C9CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27384661 | 0.78 | EPHX2 (0.39) | SMN1; SMN2CYP2C9CYP2C19RAB9AGRIN2B | |
| SCHEMBL30920325 | 0.78 | DGAT2 (0.34) | SMN1; SMN2CYP2C9CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27385168 | 0.76 | RAB9A (0.47) | SMN1; SMN2CYP3A4CYP2D6RAB9AL3MBTL1 | |
| SCHEMBL27385697 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP1A2RAB9AGRIN2BHPGD | |
| SCHEMBL27384356 | 0.73 | SMN1; SMN2 (0.40) | SMN1; SMN2CYP2C9CYP2C19RAB9AGRIN2B | |
| SCHEMBL27383346 | 0.73 | RAB9A (0.45) | SMN1; SMN2RAB9AGRIN2BMEN1LMNA | |
| SCHEMBL27384652 | 0.73 | SMN1; SMN2 (0.41) | SMN1; SMN2CYP2C9CYP2C19RAB9AL3MBTL1 | |
| SCHEMBL27382975 | 0.73 | CACNA1G (0.48) | SMN1; SMN2CYP1A2RAB9AGRIN2BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024081748-A2 | INHIBITORS OF SOLUTE CARRIER FAMILY 6A MEMBER 19 (SLC6A19) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2024-04-18 | — | — | WO | disclosed |