Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALB | P02768 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.41 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7390419 | 0.83 | GABBR2 (0.53) | MAPTCYP2D6SRCGABBR2GABBR1 | |
| SCHEMBL27957618 | 0.82 | STAT3 (0.46) | ALDH1A1HPGDLMNAPOLB | |
| SCHEMBL109205 | 0.80 | LMNA (0.53) | ALDH1A1KDM4EMAPTMTNR1AMTNR1B | |
| SCHEMBL27908869 | 0.80 | LMNA (0.49) | ALDH1A1MAPTKMT2AMEN1CYP2D6 | |
| SCHEMBL23757780 | 0.80 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTMTNR1AMTNR1B | |
| SCHEMBL27682540 | 0.79 | CYP2C19 (0.42) | MAPTCYP2D6SRCGABBR2GABBR1 | |
| SCHEMBL28846433 | 0.79 | CYP2C19 (0.51) | ALDH1A1CYP2D6SRCGABBR2GABBR1 | |
| SCHEMBL30777017 | 0.79 | KCNA5 (0.50) | ALDH1A1MAPTKMT2AMEN1HPGD | |
| SCHEMBL11097152 | 0.79 | ATM (0.57) | MAPTKMT2AMEN1HPGDLMNA | |
| SCHEMBL27957616 | 0.79 | L3MBTL1 (0.49) | KMT2ACYP2C9MEN1CYP2D6HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1921841-A | Amines and amides for the treatment of diseases | JOLLA PHARMA (US) | 2007-02-28 | — | — | CN | disclosed |
| CN-1078886-C | Inhibitors of beta-amyloid production | MURRILL MEDICINES CO (US) | 2002-02-06 | — | — | CN | disclosed |
| CN-1132504-A | Inhibitors of beta-amyloid production | MURRILL MEDICINES CO (US) | 1996-10-02 | — | — | CN | disclosed |