Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.74 |
| ▸ | HTR2C | P28335 | 5/20 | 0.74 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.74 |
| ▸ | HTR2A | P28223 | 4/20 | 0.74 |
| ▸ | DRD4 | P21917 | 4/20 | 0.74 |
| ▸ | HTR1A | P08908 | 3/20 | 0.74 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.74 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.74 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.74 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.74 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.74 |
| ▸ | DRD1 | P21728 | 3/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.74 |
| ▸ | HRH2 | P25021 | 3/20 | 0.74 |
| ▸ | HRH1 | P35367 | 3/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.74 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30173174 | 0.93 | DRD2 (0.75) | DRD2HTR2CADRA2AHTR2ADRD4 | |
| SCHEMBL142222 | 0.93 | DRD2 (0.75) | DRD2HTR2CADRA2AHTR2ADRD4 | |
| SCHEMBL31098217 | 0.86 | DRD2 (0.74) | DRD2HTR2CADRA2AHTR2ADRD4 | |
| SCHEMBL3408014 | 0.86 | HTR2A (0.71) | DRD2HTR2CADRA2AHTR2ADRD4 | |
| SCHEMBL2615196 | 0.86 | DRD2 (0.74) | DRD2HTR2CADRA2AHTR2ADRD4 | |
| SCHEMBL13285190 | 0.86 | DRD2 (0.74) | DRD2HTR2CADRA2AHTR2ADRD4 | |
| Amoxapine SCHEMBL33950 | 0.85 | DRD2 (1.00) | DRD2HTR2CADRA2AHTR2ADRD4 | |
| Amoxapine SCHEMBL29354942 | 0.85 | DRD2 (1.00) | DRD2HTR2CADRA2AHTR2ADRD4 | |
| Amoxapine SCHEMBL29482386 | 0.85 | DRD2 (1.00) | DRD2HTR2CADRA2AHTR2ADRD4 | |
| Amoxapine SCHEMBL29370074 | 0.85 | DRD2 (1.00) | DRD2HTR2CADRA2AHTR2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088918-B2 | Noncardiotoxic pharmaceutical compounds | WILLIAMSBURG HOLDINGS LLC (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088918-B2 | Noncardiotoxic pharmaceutical compounds | WILLIAMSBURG HOLDINGS LLC (US) | 2012-01-03 | — | — | US | disclosed |