Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.75 |
| ▸ | HTR2A | P28223 | 4/20 | 0.75 |
| ▸ | HRH1 | P35367 | 4/20 | 0.75 |
| ▸ | HTR2C | P28335 | 4/20 | 0.75 |
| ▸ | HTR1A | P08908 | 3/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.75 |
| ▸ | HRH2 | P25021 | 3/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.75 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.75 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.75 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.75 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.75 |
| ▸ | DRD1 | P21728 | 3/20 | 0.75 |
| ▸ | DRD4 | P21917 | 3/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.75 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.75 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30173174 | 1.00 | DRD2 (0.75) | DRD2HTR2AHRH1HTR2CHTR1A | |
| SCHEMBL2738764 | 0.93 | DRD2 (0.74) | DRD2HTR2AHRH1HTR2CHTR1A | |
| SCHEMBL3412948 | 0.86 | HRH1 (0.71) | DRD2HTR2AHRH1HTR2CHTR1A | |
| SCHEMBL11882173 | 0.86 | HRH4 (0.75) | DRD2HTR2AHRH1HTR2CHTR1A | |
| Amoxapine SCHEMBL29370074 | 0.86 | DRD2 (1.00) | DRD2HTR2AHRH1HTR2CHTR1A | |
| Amoxapine SCHEMBL29482386 | 0.86 | DRD2 (1.00) | DRD2HTR2AHRH1HTR2CHTR1A | |
| Amoxapine SCHEMBL33950 | 0.86 | DRD2 (1.00) | DRD2HTR2AHRH1HTR2CHTR1A | |
| Amoxapine SCHEMBL29354942 | 0.86 | DRD2 (1.00) | DRD2HTR2AHRH1HTR2CHTR1A | |
| Amoxapine SCHEMBL5498936 | 0.86 | DRD2 (1.00) | DRD2HTR2AHRH1HTR2CHTR1A | |
| Amoxapine SCHEMBL29180215 | 0.85 | DRD2 (0.98) | DRD2HTR2AHRH1HTR2CHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 230 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| EP-4297868-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | Hoth Therapeutics, Inc. (US) | 2024-01-03 | — | — | EP | claimed |
| WO-2022182658-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. (US) | 2022-09-01 | — | — | WO | claimed |
| EP-1414466-B1 | COMBINATIONS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | COMBINATORX INC (US) | 2009-08-19 | — | — | EP | claimed |
| US-20080280863-A1 | COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | COMBINATORX, INCORPORATED | 2008-11-13 | — | — | US | claimed |
| US-7335371-B2 | Combinations for the treatment of inflammatory disorders | COMBINATORX, INCORPORATED (US) | 2008-02-26 | — | — | US | claimed |
| EP-1414466-A4 | COMBINATIONS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | COMBINATORX INC (US) | 2006-06-07 | — | — | EP | claimed |
| US-6897206-B2 | Combinations for the treatment of inflammatory disorders | COMBINATORX, INC. (US) | 2005-05-24 | — | — | US | claimed |
| US-20040110734-A1 | Combinations for the treatment of inflammatory disorders | ZALICUS INC. | 2004-06-10 | — | — | US | claimed |
| EP-1414466-A1 | COMBINATIONS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | Combinatorx, Incorporated (US) | 2004-05-06 | — | — | EP | claimed |
| US-20030078246-A1 | Combinations for the treatment of inflammatory disorders | ZALICUS INC. | 2003-04-24 | — | — | US | claimed |
| WO-2003006026-A1 | COMBINATIONS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | COMBINATORX, INCORPORATED (US) | 2003-01-23 | — | — | WO | claimed |
| US-20260055116-A1 | SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | KARUNA THERAPEUTICS INC (US) | 2026-02-26 | — | — | US | disclosed |
| US-20250333441-A1 | POLYPEPTIDE INHIBITORS AND USES THEREOF | NEURACLE SCIENCE CO., LTD. (KR) | 2025-10-30 | — | — | US | disclosed |
| EP-4634193-A1 | SUBSTITUTED DIHYDROPYRROLO[3, 4-D]PYRIMIDINE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Karuna Therapeutics, Inc. (US) | 2025-10-22 | — | — | EP | disclosed |
| EP-4634194-A1 | SUBSTITUTED DIHYDROPYRROLO [3, 4-D] PYRIMIDINE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Karuna Therapeutics, Inc. (US) | 2025-10-22 | — | — | EP | disclosed |
| US-20040110734-A1 | Combinations for the treatment of inflammatory disorders | ZALICUS INC. | 2004-06-10 | — | — | US | disclosed |
| EP-1414466-A1 | COMBINATIONS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | Combinatorx, Incorporated (US) | 2004-05-06 | — | — | EP | disclosed |
| US-20030078246-A1 | Combinations for the treatment of inflammatory disorders | ZALICUS INC. | 2003-04-24 | — | — | US | disclosed |
| WO-2003006026-A1 | COMBINATIONS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | COMBINATORX, INCORPORATED (US) | 2003-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078246-A1 | Combinations for the treatment of inflammatory disorders | IL6, FKBP1B, NR3C1 | DRD2 911/4885HTR2A 121/4885HRH1 790/4885 |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | TACR1, ACHE, TACR2 | DRD2 911/4885HTR2A 207/4885HRH1 191/4885 |
| US-20250333441-A1 | POLYPEPTIDE INHIBITORS AND USES THEREOF | LRRC59, FAM20C, LRRFIP1 | DRD2 4497/4885HTR2A 4172/4885HRH1 4307/4885 |
| US-20080280863-A1 | COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | TNF, MPO, IL5 | DRD2 4822/4885HTR2A 3696/4885HRH1 1643/4885 |
| US-20040110734-A1 | Combinations for the treatment of inflammatory disorders | TNF, IL2, CD68 | DRD2 4728/4885HTR2A 3730/4885HRH1 1824/4885 |
| US-20260055116-A1 | SUBSTITUTED TETRAHYDROPYRROLO-PYRIDINONE COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | CHRM3, CHRM2, CHRM1 | DRD2 595/4885HTR2A 183/4885HRH1 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.