Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30905539 | 0.87 | IKBKB (0.41) | MKNK1MKNK2IKBKBPDE4BBRD4 | |
| SCHEMBL27397408 | 0.87 | IKBKB (0.41) | MKNK1MKNK2IKBKBPDE4BBRD4 | |
| SCHEMBL27398651 | 0.86 | LCK (0.37) | MKNK1MKNK2IKBKBLCKBTK | |
| SCHEMBL27399330 | 0.85 | DHODH (0.39) | MKNK1MKNK2LCKBTKPRMT5 | |
| SCHEMBL27399923 | 0.84 | BRD4 (0.35) | MKNK1MKNK2IKBKBPDE4BBRD4 | |
| SCHEMBL27400738 | 0.82 | LCK (0.37) | MKNK1MKNK2LCKBTKPKMYT1 | |
| SCHEMBL27399600 | 0.82 | IRAK4 (0.35) | MKNK1MKNK2IKBKBLCKBTK | |
| SCHEMBL27401362 | 0.82 | PKMYT1 (0.44) | IKBKBPDE4BKDM4EALDH1A1PKMYT1 | |
| SCHEMBL27399014 | 0.81 | LCK (0.51) | MKNK1MKNK2IKBKBLCKBTK | |
| SCHEMBL27399603 | 0.81 | MKNK1 (0.40) | MKNK1MKNK2IKBKBLCKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |