Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27398651 | 0.85 | LCK (0.37) | LCKBTKPKMYT1PRMT5PARP1 | |
| SCHEMBL27399330 | 0.84 | DHODH (0.39) | LCKBTKGRM2PRMT5CYP11B1 | |
| SCHEMBL27399014 | 0.83 | LCK (0.51) | LCKBTKPRMT5CYP11B2PARP1 | |
| SCHEMBL27398649 | 0.82 | MKNK1 (0.35) | LCKBTKPKMYT1PRMT5ADORA2A | |
| SCHEMBL27399921 | 0.80 | PDE4A (0.44) | PKMYT1GRM2PRMT5PARP1LMNA | |
| SCHEMBL27399603 | 0.80 | MKNK1 (0.40) | LCKBTKPRMT5PARP1ADORA2A | |
| SCHEMBL27399933 | 0.79 | PRMT5 (0.41) | LCKBTKPRMT5PARP1LMNA | |
| SCHEMBL27399247 | 0.78 | MKNK1 (0.50) | LCKBTKPRMT5PARP1ELANE | |
| SCHEMBL27400004 | 0.78 | IKBKB (0.35) | LCKBTKPRMT5PARP1MKNK1 | |
| SCHEMBL27400121 | 0.78 | PRMT5 (0.39) | LCKBTKPKMYT1PRMT5PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |