Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | COMT | P21964 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | PKMYT1 | Q99640 | 3/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | FRK | P42685 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27399916 | 0.91 | PRMT5 (0.38) | PRMT5KDRKDM4EPARP1MKNK2 | |
| SCHEMBL27398651 | 0.88 | LCK (0.37) | PRMT5KDRKDM4EPARP1MKNK2 | |
| SCHEMBL27397409 | 0.87 | PKMYT1 (0.42) | PRMT5KDM4EPARP1MKNK2MKNK1 | |
| SCHEMBL30905534 | 0.87 | PKMYT1 (0.42) | PRMT5KDM4EPARP1MKNK2MKNK1 | |
| SCHEMBL27399247 | 0.82 | MKNK1 (0.50) | PRMT5KDM4EPARP1MKNK2MKNK1 | |
| SCHEMBL27400121 | 0.82 | PRMT5 (0.39) | PRMT5KDRPARP1MKNK2MKNK1 | |
| SCHEMBL30905573 | 0.81 | PKMYT1 (0.42) | PRMT5KDM4EPARP1LMNAPKMYT1 | |
| SCHEMBL27397362 | 0.81 | PKMYT1 (0.42) | PRMT5KDM4EPARP1LMNAPKMYT1 | |
| SCHEMBL27399330 | 0.80 | DHODH (0.39) | PRMT5PARP1MKNK2MKNK1LIMK1 | |
| SCHEMBL27399927 | 0.80 | LIMK1 (0.37) | PRMT5KDM4EPARP1MKNK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |