Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.34 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.34 |
| ▸ | PRF1 | P14222 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27400754 | 0.78 | KDM4E (0.40) | EGFRKDM4EALDH1A1LIMK1PARP1 | |
| SCHEMBL27399247 | 0.75 | MKNK1 (0.50) | DYRK1AKDM4EALDH1A1TGFBR1LIMK1 | |
| SCHEMBL27399933 | 0.74 | PRMT5 (0.41) | DYRK1AIRAK4EGFRACVR1KDM4E | |
| SCHEMBL27400748 | 0.74 | CDK9 (0.39) | DYRK1ACDK4CDK2GSK3BTGFBR1 | |
| SCHEMBL27400870 | 0.74 | SYK (0.36) | DYRK1AKDM4ELIMK1PARP1 | |
| SCHEMBL27399014 | 0.73 | LCK (0.51) | DYRK1ALIMK1PARP1 | |
| SCHEMBL27399603 | 0.73 | MKNK1 (0.40) | DYRK1AKDM4EALDH1A1LIMK1PARP1 | |
| SCHEMBL27400004 | 0.73 | IKBKB (0.35) | DYRK1ALIMK1PARP1 | |
| SCHEMBL27399335 | 0.73 | PRMT5 (0.39) | DYRK1APLK1CDK2KDM4ELIMK1 | |
| SCHEMBL27398651 | 0.72 | LCK (0.37) | DYRK1AKDM4ELIMK1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |