Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLM | Q9NP87 | 2/20 | 0.52 |
| ▸ | POLK | Q9UBT6 | 2/20 | 0.52 |
| ▸ | POLL | Q9UGP5 | 2/20 | 0.52 |
| ▸ | POLH | Q9Y253 | 2/20 | 0.52 |
| ▸ | TOP1 | P11387 | 3/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27370235 | 0.88 | POLM (0.60) | POLMPOLKPOLLPOLHTOP1 | |
| SCHEMBL27461372 | 0.84 | POLM (0.46) | POLMPOLKPOLLPOLHTOP1 | |
| SCHEMBL27369443 | 0.82 | PIM1 (0.46) | POLMPOLKPOLLPOLHTOP1 | |
| SCHEMBL6367288 | 0.76 | ELANE (0.55) | POLMPOLKPOLLPOLHALDH1A1 | |
| SCHEMBL27366686 | 0.75 | TYMS (0.47) | POLMPOLKPOLLPOLHTOP1 | |
| SCHEMBL29018326 | 0.74 | TOP1 (0.67) | TOP1PTPRCALDH1A1MAPTACHE | |
| SCHEMBL8435546 | 0.73 | ALOX15 (0.55) | ALDH1A1MAPTACHEALOX15ESR1 | |
| SCHEMBL27602059 | 0.73 | ELANE (0.56) | POLMPOLKPOLLPOLHALDH1A1 | |
| SCHEMBL27558184 | 0.73 | PTPRC (0.55) | POLMPOLKPOLLPOLHTOP1 | |
| SCHEMBL7921268 | 0.72 | ACHE (0.46) | POLMPOLKPOLLPOLHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1063180-C | 5H, 10H-imidazo [1, 2 -a] indeno [1, 2 -e] pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE POULENC RORER SA (FR) | 2001-03-14 | — | — | CN | disclosed |
| CN-1180357-A | 5H, 10H-imidazo [1, 2-a ] indeno [1, 2-e ] pyrazin-4-one derivatives, preparation thereof and medicaments containing same | RHONE POULENC RORER SA (FR) | 1998-04-29 | — | — | CN | disclosed |