Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLM | Q9NP87 | 2/20 | 0.46 |
| ▸ | POLK | Q9UBT6 | 2/20 | 0.46 |
| ▸ | POLL | Q9UGP5 | 2/20 | 0.46 |
| ▸ | POLH | Q9Y253 | 2/20 | 0.46 |
| ▸ | TOP1 | P11387 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27407860 | 0.84 | POLM (0.52) | POLMPOLKPOLLPOLHTOP1 | |
| SCHEMBL27370235 | 0.81 | POLM (0.60) | POLMPOLKPOLLPOLHTOP1 | |
| SCHEMBL27369443 | 0.79 | PIM1 (0.46) | POLMPOLKPOLLPOLHTOP1 | |
| SCHEMBL15548526 | 0.78 | KMT2A (0.49) | KMT2AKDM4EL3MBTL1APEX1POLB | |
| SCHEMBL15447050 | 0.77 | KMT2A (0.42) | KMT2AKDM4EL3MBTL1APEX1POLB | |
| SCHEMBL825432 | 0.75 | KDM4E (0.51) | KMT2AKDM4EL3MBTL1ALDH1A1MAPT | |
| SCHEMBL12216149 | 0.74 | KMT2A (0.38) | POLMPOLKPOLLPOLHKMT2A | |
| SCHEMBL4085152 | 0.72 | KMT2A (0.49) | KMT2AKDM4EL3MBTL1POLBATM | |
| SCHEMBL4090840 | 0.72 | TDP1 (0.48) | KMT2AKDM4EL3MBTL1ATMALDH1A1 | |
| SCHEMBL17459128 | 0.72 | L3MBTL1 (0.44) | KMT2AKDM4EL3MBTL1APEX1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1063180-C | 5H, 10H-imidazo [1, 2 -a] indeno [1, 2 -e] pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE POULENC RORER SA (FR) | 2001-03-14 | — | — | CN | disclosed |
| CN-1180357-A | 5H, 10H-imidazo [1, 2-a ] indeno [1, 2-e ] pyrazin-4-one derivatives, preparation thereof and medicaments containing same | RHONE POULENC RORER SA (FR) | 1998-04-29 | — | — | CN | disclosed |