Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.34 |
| ▸ | TUBB | P07437 | 3/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27408994 | 0.80 | KDM4E (0.39) | MAPTALDH1A1KDM4ECCNCCDK8 | |
| SCHEMBL27409003 | 0.79 | ADORA1 (0.35) | MAPTALDH1A1KDM4ECCNCCDK8 | |
| SCHEMBL16741126 | 0.71 | TPH1 (0.40) | CCNCCDK8 | |
| SCHEMBL14031549 | 0.71 | PDPK1 (0.40) | MAPTKDM4ECCNCCDK8TUBB4A | |
| SCHEMBL13766600 | 0.69 | TGFBR1 (0.38) | MAPTALDH1A1CCNCCDK8SMN1; SMN2 | |
| SCHEMBL26260076 | 0.68 | HIF1A (0.41) | MAPTALDH1A1KDM4EACLYTUBB4A | |
| SCHEMBL8285706 | 0.68 | S1PR4 (0.50) | MAPTALDH1A1KDM4ESMN1; SMN2USP2 | |
| SCHEMBL29813462 | 0.68 | SMN1; SMN2 (0.59) | MAPTALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL30849054 | 0.67 | TUBB4A (0.34) | KDM4EACLYTUBB4ATUBBTUBA3C | |
| SCHEMBL12924082 | 0.67 | LTA4H (0.42) | MEN1KMT2ARAB9ALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024076891-A1 | POLO LIKE KINASE 4 INHIBITORS | ORIC PHARMACEUTICALS, INC. (US) | 2024-04-11 | — | — | WO | disclosed |