Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.66 |
| ▸ | MEN1 | O00255 | 8/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.66 |
| ▸ | LMNA | P02545 | 10/20 | 0.66 |
| ▸ | HTT | P42858 | 7/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | GAA | P10253 | 4/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.66 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.66 |
| ▸ | XBP1 | P17861 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.54 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17774670 | 0.76 | MAPT (0.79) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL12653717 | 0.73 | ALDH1A1 (0.74) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL20063250 | 0.72 | ALDH1A1 (0.74) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL2740969 | 0.72 | CA1 (0.56) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL14744061 | 0.70 | RORC (0.71) | LMNAGAAMCOLN3 | |
| SCHEMBL17774604 | 0.69 | MAPT (0.78) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL24711784 | 0.69 | ALDH1A1 (0.73) | MAPTKMT2ALMNAHTTKDM4E | |
| SCHEMBL12653700 | 0.69 | LMNA (0.66) | MAPTKMT2ALMNAHTTKDM4E | |
| SCHEMBL4924780 | 0.68 | MAPT (0.77) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL7156743 | 0.66 | SMN1; SMN2 (1.00) | MAPTMEN1KMT2AHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088772-B2 | Sulfonamides and their use as a medicament | THE GENETICS COMPANY, INC. (CH) | 2012-01-03 | — | — | US | disclosed |
| US-8088772-B2 | Sulfonamides and their use as a medicament | THE GENETICS COMPANY, INC. (CH) | 2012-01-03 | — | — | US | disclosed |
| US-20100249135-A1 | SULFONAMIDES AND THEIR USE AS A MEDICAMENT | THE GENETICS COMPANY, INC. (CH) | 2010-09-30 | — | — | US | disclosed |
| US-20100249135-A1 | SULFONAMIDES AND THEIR USE AS A MEDICAMENT | THE GENETICS COMPANY, INC. (CH) | 2010-09-30 | — | — | US | disclosed |
| EP-1932830-A1 | Sulfonamides and their use as a medicament | The Genetics Company, Inc. (CH) | 2008-06-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249135-A1 | SULFONAMIDES AND THEIR USE AS A MEDICAMENT | BCOR, CBR3, SULT1E1 | MAPT 4202/4885MEN1 1381/4885KMT2A 217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.