Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL225811 | 1.00 | EPHX2 (0.49) | EPHX2SLC9A1PKMRAB9AFAAH | |
| SCHEMBL225810 | 1.00 | EPHX2 (0.49) | EPHX2SLC9A1PKMRAB9AFAAH | |
| SCHEMBL15254635 | 0.85 | EPHX2 (0.52) | EPHX2SLC9A1MCL1L3MBTL1GPR88 | |
| SCHEMBL6250729 | 0.85 | MAPT (0.51) | EPHX2RAB9AMCL1L3MBTL1GPR88 | |
| SCHEMBL5683647 | 0.85 | EPHX2 (0.52) | EPHX2SLC9A1MCL1L3MBTL1GPR88 | |
| SCHEMBL15254908 | 0.85 | EPHX2 (0.52) | EPHX2SLC9A1MCL1L3MBTL1GPR88 | |
| SCHEMBL17590033 | 0.84 | MCL1 (0.55) | EPHX2SLC9A1MCL1GPR88 | |
| SCHEMBL15208924 | 0.84 | MCL1 (0.55) | EPHX2SLC9A1MCL1GPR88 | |
| SCHEMBL17146213 | 0.84 | MCL1 (0.55) | EPHX2SLC9A1MCL1GPR88 | |
| SCHEMBL13929891 | 0.84 | MCL1 (0.55) | EPHX2SLC9A1MCL1GPR88 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230144767-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2023-05-11 | — | — | US | disclosed |
| US-9890192-B2 | Targeted nitroxide agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2018-02-13 | — | — | US | disclosed |
| US-9732105-B2 | Targeted nitroxide agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-08-15 | — | — | US | disclosed |
| US-20160137692-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-05-19 | — | — | US | disclosed |
| US-20160068556-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-03-10 | — | — | US | disclosed |
| US-9220711-B2 | Compounds for the treatment of pathologies associated with aging and degenerative disorders | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-12-29 | — | — | US | disclosed |
| US-9216976-B2 | Targeted nitroxide agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-12-22 | — | — | US | disclosed |
| US-8937086-B2 | Compounds for the treatment of pathologies associated with aging and degenerative disorders | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-01-20 | — | — | US | disclosed |
| US-20140378444-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-12-25 | — | — | US | disclosed |
| US-8822541-B2 | Use of targeted nitroxide agents in mitigating or treating radiation injury | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2014-09-02 | — | — | US | disclosed |
| US-20140018317-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-01-16 | — | — | US | disclosed |
| US-8487079-B2 | Use of mitochondria-targeted electron scavengers as anti-inflammatory agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2013-07-16 | — | — | US | disclosed |
| US-20130102626-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2013-04-25 | — | — | US | disclosed |
| US-8288551-B2 | Targeted nitroxide agents | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-10-16 | — | — | US | disclosed |
| US-20120004263-A1 | Compounds for the treatment of pathologies associated with aging and degenerative disorders | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-01-05 | — | — | US | disclosed |
| US-20110172214-A1 | USE OF TARGETED NITROXIDE AGENTS IN PREVENTING, MITIGATING AND TREATING RADIATION INJURY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2011-07-14 | — | — | US | disclosed |
| US-20100035869-A1 | TARGETED NITROXIDE AGENTS | PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UNIVERSITY OF | 2010-02-11 | — | — | US | disclosed |
| US-20090042808-A1 | USE OF MITOCHONDRIA-TARGETED ELECTRON SCAVENGERS AS ANTI-INFLAMMATORY AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172214-A1 | USE OF TARGETED NITROXIDE AGENTS IN PREVENTING, MITIGATING AND TREATING RADIATION INJURY | TXNRD2, TXN2, HSPE1 | EPHX2 2186/4885SLC9A1 2168/4885PKM 1140/4885 |
| US-20160137692-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | EPHX2 2346/4885SLC9A1 2325/4885PKM 1205/4885 |
| US-20120004263-A1 | Compounds for the treatment of pathologies associated with aging and degenerative disorders | GLA, AGER, SIRT1 | EPHX2 3558/4885SLC9A1 3641/4885PKM 979/4885 |
| US-20090042808-A1 | USE OF MITOCHONDRIA-TARGETED ELECTRON SCAVENGERS AS ANTI-INFLAMMATORY AGENTS | HAGH, COX5B, HSPE1 | EPHX2 3231/4885SLC9A1 3025/4885PKM 1931/4885 |
| US-20100035869-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | EPHX2 2346/4885SLC9A1 2325/4885PKM 1205/4885 |
| US-20230144767-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | EPHX2 2346/4885SLC9A1 2325/4885PKM 1205/4885 |
| US-20140018317-A1 | TARGETED NITROXIDE AGENTS | NOXO1, NOX1, TPX2 | EPHX2 738/4885SLC9A1 2541/4885PKM 3180/4885 |
| US-20140378444-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | EPHX2 2346/4885SLC9A1 2325/4885PKM 1205/4885 |
| US-20160068556-A1 | TARGETED NITROXIDE AGENTS | NOXO1, NOX1, TPX2 | EPHX2 738/4885SLC9A1 2541/4885PKM 3180/4885 |
| US-20130102626-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | EPHX2 2346/4885SLC9A1 2325/4885PKM 1205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.