Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.38 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2761508 | 1.00 | POLB (0.43) | POLBTSHRHSD11B1NPC1RAB9A | |
| SCHEMBL25913566 | 0.81 | POLB (0.48) | POLBTSHRHSD11B1NPC1RAB9A | |
| SCHEMBL14697193 | 0.74 | EPHX1 (0.48) | — | |
| SCHEMBL20863628 | 0.74 | ITK (0.35) | — | |
| SCHEMBL34462074 | 0.73 | POLB (0.53) | POLBTSHRHSD11B1NPC1RAB9A | |
| SCHEMBL17518655 | 0.73 | POLB (0.53) | POLBTSHRHSD11B1NPC1RAB9A | |
| SCHEMBL18628997 | 0.73 | POLB (0.53) | POLBTSHRHSD11B1NPC1RAB9A | |
| SCHEMBL1105066 | 0.73 | POLB (0.53) | POLBTSHRHSD11B1NPC1RAB9A | |
| SCHEMBL21420047 | 0.72 | EPHX2 (0.34) | — | |
| SCHEMBL6982537 | 0.72 | EPHX2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890192-B2 | Targeted nitroxide agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2018-02-13 | — | — | US | disclosed |
| US-9732105-B2 | Targeted nitroxide agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-08-15 | — | — | US | disclosed |
| US-20160137692-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-05-19 | — | — | US | disclosed |
| US-20160068556-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-03-10 | — | — | US | disclosed |
| US-9220711-B2 | Compounds for the treatment of pathologies associated with aging and degenerative disorders | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-12-29 | — | — | US | disclosed |
| US-9216976-B2 | Targeted nitroxide agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-12-22 | — | — | US | disclosed |
| US-8937086-B2 | Compounds for the treatment of pathologies associated with aging and degenerative disorders | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-01-20 | — | — | US | disclosed |
| US-20140378444-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-12-25 | — | — | US | disclosed |
| US-8822541-B2 | Use of targeted nitroxide agents in mitigating or treating radiation injury | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2014-09-02 | — | — | US | disclosed |
| US-20140018317-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-01-16 | — | — | US | disclosed |
| US-20130102626-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2013-04-25 | — | — | US | disclosed |
| US-8288551-B2 | Targeted nitroxide agents | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-10-16 | — | — | US | disclosed |
| US-20120004263-A1 | Compounds for the treatment of pathologies associated with aging and degenerative disorders | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-01-05 | — | — | US | disclosed |
| US-20110172214-A1 | USE OF TARGETED NITROXIDE AGENTS IN PREVENTING, MITIGATING AND TREATING RADIATION INJURY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2011-07-14 | — | — | US | disclosed |
| US-20100035869-A1 | TARGETED NITROXIDE AGENTS | PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UNIVERSITY OF | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172214-A1 | USE OF TARGETED NITROXIDE AGENTS IN PREVENTING, MITIGATING AND TREATING RADIATION INJURY | TXNRD2, TXN2, HSPE1 | POLB 434/4885TSHR 4274/4885HSD11B1 2560/4885 |
| US-20160137692-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | POLB 394/4885TSHR 3984/4885HSD11B1 2734/4885 |
| US-20120004263-A1 | Compounds for the treatment of pathologies associated with aging and degenerative disorders | GLA, AGER, SIRT1 | POLB 431/4885TSHR 3189/4885HSD11B1 1311/4885 |
| US-20100035869-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | POLB 394/4885TSHR 3984/4885HSD11B1 2734/4885 |
| US-20140018317-A1 | TARGETED NITROXIDE AGENTS | NOXO1, NOX1, TPX2 | POLB 1683/4885TSHR 2544/4885HSD11B1 3052/4885 |
| US-20140378444-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | POLB 394/4885TSHR 3984/4885HSD11B1 2734/4885 |
| US-20160068556-A1 | TARGETED NITROXIDE AGENTS | NOXO1, NOX1, TPX2 | POLB 1683/4885TSHR 2544/4885HSD11B1 3052/4885 |
| US-20130102626-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | POLB 394/4885TSHR 3984/4885HSD11B1 2734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.