Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30475863 | 0.78 | ESR1 (0.57) | OPRD1OPRM1SLC6A4ACHESLC22A1 | |
| SCHEMBL3946783 | 0.76 | OPRM1 (0.47) | OPRD1OPRM1SLC6A4ACHESLC22A1 | |
| SCHEMBL14531297 | 0.76 | AKR1C1 (0.67) | CYP2D6MEN1KMT2A | |
| SCHEMBL5808986 | 0.74 | OPRD1 (0.67) | OPRD1OPRM1SLC6A4ACHESLC22A1 | |
| SCHEMBL7802441 | 0.74 | LMNA (0.53) | OPRD1LMNA | |
| SCHEMBL6417291 | 0.74 | AKR1C1 (0.65) | CYP2D6MEN1KMT2A | |
| SCHEMBL12020311 | 0.74 | HDAC4 (0.49) | OPRD1OPRM1SLC6A4ACHESLC22A1 | |
| SCHEMBL19646503 | 0.73 | ESR1 (0.57) | OPRD1OPRM1ACHEOPRK1ALDH1A1 | |
| SCHEMBL27906398 | 0.72 | SLC6A4 (0.50) | SLC6A4SLC6A2MEN1KMT2AALDH1A1 | |
| SCHEMBL15021523 | 0.72 | OPRD1 (0.46) | OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1109683-C | 2-arylbenzo [ b ] thiophenes for the treatment of estrogen deficiency syndrome | LILLY CO ELI (US) | 2003-05-28 | — | — | CN | claimed |
| CN-1278811-A | 2-arylbenzo [ b ] thiophenes for the treatment of estrogen deficiency syndrome | LILLY CO ELI (US) | 2001-01-03 | — | — | CN | claimed |
| CN-1109683-C | 2-arylbenzo [ b ] thiophenes for the treatment of estrogen deficiency syndrome | LILLY CO ELI (US) | 2003-05-28 | — | — | CN | disclosed |
| CN-1278811-A | 2-arylbenzo [ b ] thiophenes for the treatment of estrogen deficiency syndrome | LILLY CO ELI (US) | 2001-01-03 | — | — | CN | disclosed |