Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 4/20 | 0.47 |
| ▸ | MMP12 | P39900 | 4/20 | 0.47 |
| ▸ | MMP9 | P14780 | 3/20 | 0.47 |
| ▸ | MMP1 | P03956 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | STAT1 | P42224 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27477137 | 0.81 | TDP1 (0.46) | RAB9ANPC1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20111506 | 0.78 | ALDH1A1 (0.51) | RAB9ANPC1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL21594758 | 0.75 | SMN1; SMN2 (0.53) | RAB9ANPC1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20656207 | 0.74 | MMP2 (0.47) | RAB9ANPC1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1621986 | 0.74 | KMT2A (0.65) | RAB9ANPC1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3412144 | 0.73 | TDP1 (0.51) | RAB9ANPC1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8388918 | 0.73 | RAB9A (0.57) | RAB9ANPC1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL23019130 | 0.73 | RAB9A (0.55) | RAB9ANPC1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20646585 | 0.73 | MMP2 (0.46) | RAB9ANPC1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL9528064 | 0.72 | TDP1 (0.53) | RAB9ANPC1KMT2AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1125051-C | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors | DIMENSIONAL PHARM INC (US) | 2003-10-22 | — | — | CN | disclosed |
| CN-1283189-A | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors | DIMENSIONAL PHARM INC (US) | 2001-02-07 | — | — | CN | disclosed |