SCHEMBL27435408

SCHEMBL27435408

COC(=O)c1c(OC)c(Cl)cc2c1OCCN2Cc1ccsc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.40
HSP90B1 P14625 1/20 0.40
ALDH1A1 P00352 3/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
DRD3 P35462 2/20 0.34
HTR1A P08908 1/20 0.34
DRD2 P14416 1/20 0.34
DRD4 P21917 1/20 0.34
HTR2A P28223 1/20 0.34
HTR2C P28335 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
PTGER2 P43116 1/20 0.33
ROCK2 O75116 1/20 0.33
ROCK1 Q13464 1/20 0.33
NSD2 O96028 1/20 0.33
KDM4E B2RXH2 1/20 0.33
GLA P06280 1/20 0.33
GAA P10253 1/20 0.33
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30954048 0.91 ALDH1A1 (0.36) HSP90AA1HSP90B1ALDH1A1MEN1KMT2A
SCHEMBL27435420 0.91 ALDH1A1 (0.36) HSP90AA1HSP90B1ALDH1A1MEN1KMT2A
SCHEMBL27435508 0.87 DRD3 (0.41) ALDH1A1MEN1KMT2ADRD3DRD2
SCHEMBL27435244 0.86 TP53 (0.43) ALDH1A1MEN1KMT2ASMN1; SMN2KDM4E
SCHEMBL30954135 0.84 POLB (0.44) HSP90AA1HSP90B1ALDH1A1MEN1KMT2A
SCHEMBL27433845 0.84 POLB (0.44) HSP90AA1HSP90B1ALDH1A1MEN1KMT2A
SCHEMBL27435327 0.82 DRD2 (0.40) MEN1KMT2ADRD3HTR1ADRD2
SCHEMBL27435439 0.80 HSP90B1 (0.44) HSP90AA1HSP90B1KMT2AHTR2CMAPK1
SCHEMBL27435528 0.79 KCNA3 (0.41) ALDH1A1DRD3DRD2KDM4E
SCHEMBL27435364 0.79 KCNA3 (0.42) ALDH1A1DRD3HTR1ADRD2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4630412-A1 COMPOUNDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS NMD Pharma A/S (DK) 2025-10-15 EP disclosed
WO-2024121130-A1 COMPOUNDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS NMD PHARMA A/S (DK) 2024-06-13 WO disclosed
WO-2024121130-A1 COMPOUNDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS NMD PHARMA A/S (DK) 2024-06-13 WO disclosed