Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL6524533 | 0.85 | LMNA (0.56) | ALDH1A1LMNATHRBMAPTKDM4E | |
| Trolamine SCHEMBL11472536 | 0.85 | MAPT (0.40) | LMNAMAPTKDM4E | |
| Trolamine SCHEMBL28274608 | 0.83 | LMNA (0.53) | ALDH1A1LMNATHRBMAPTKDM4E | |
| Trolamine SCHEMBL28100199 | 0.83 | LMNA (0.53) | ALDH1A1LMNATHRBMAPTKDM4E | |
| Trolamine SCHEMBL27661615 | 0.81 | TDP1 (0.50) | ALDH1A1LMNATHRBMAPTKDM4E | |
| Trolamine SCHEMBL28109599 | 0.78 | LMNA (0.47) | ALDH1A1LMNATHRBKDM4E | |
| Trolamine SCHEMBL27336459 | 0.78 | MAPT (0.38) | LMNAMAPTKDM4E | |
| Glycerin SCHEMBL28864908 | 0.77 | LMNA (0.60) | ALDH1A1LMNATHRBMAPT | |
| Trolamine SCHEMBL28130412 | 0.77 | MAPT (0.42) | ALDH1A1LMNAMAPTKDM4E | |
| Glycerin SCHEMBL5691791 | 0.76 | LMNA (0.39) | ALDH1A1LMNATHRBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1041653-C | Direct measuring method of steel single-rare-earth solid solution capacity | UNIV BEIJING SCIENCE & TECH (CN) | 1999-01-13 | — | — | CN | claimed |
| CN-1120167-A | Direct measuring method of steel single-rare-earth solid solution capacity | UNIV BEIJING SCIENCE & TECH (CN) | 1996-04-10 | — | — | CN | claimed |