Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27440494 | 0.91 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1RAB9AMAPTKDM4E | |
| SCHEMBL27440492 | 0.76 | ACHE (0.35) | SMN1; SMN2ALDH1A1RAB9AMAPTKDM4E | |
| SCHEMBL27440490 | 0.76 | ALDH1A1 (0.33) | SMN1; SMN2ALDH1A1RAB9AMAPTKDM4E | |
| SCHEMBL4894905 | 0.73 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1RAB9AMAPTKDM4E | |
| SCHEMBL27404178 | 0.73 | KDM4E (0.50) | SMN1; SMN2ALDH1A1RAB9AMAPTKDM4E | |
| SCHEMBL10356745 | 0.73 | RAB9A (0.46) | SMN1; SMN2ALDH1A1RAB9AMAPTKDM4E | |
| SCHEMBL27440495 | 0.70 | EIF2AK1 (0.33) | SMN1; SMN2ALDH1A1RAB9AMAPTKDM4E | |
| SCHEMBL17666102 | 0.67 | NPC1 (0.46) | SMN1; SMN2ALDH1A1RAB9AMAPTKDM4E | |
| SCHEMBL27440497 | 0.67 | ACHE (0.37) | SMN1; SMN2ALDH1A1RAB9AMAPTKDM4E | |
| SCHEMBL27440498 | 0.67 | C5AR1 (0.36) | SMN1; SMN2ALDH1A1RAB9AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030890-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | MERCK PATENT GMBH (DE) | 2024-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030890-B2 | Compounds with diazadibenzofurane or diazadibenzothiophene structures | DDT, ESD, DBF4 | SMN1; SMN2 4234/4885ALDH1A1 722/4885RAB9A 4562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.