Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.41 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2743552 | 0.81 | KDM4E (0.57) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL26768913 | 0.78 | KDM4E (0.52) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4039660 | 0.76 | ERN1 (0.49) | KDM4EALDH1A1ERN1HSD17B10 | |
| SCHEMBL4476198 | 0.75 | TRIM24 (0.59) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6069413 | 0.75 | MAOB (0.49) | KDM4EERN1GAAMAPT | |
| SCHEMBL30009450 | 0.75 | KDM4E (0.80) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL22345013 | 0.75 | KDM4E (0.80) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2743529 | 0.73 | ALDH1A1 (0.57) | KDM4EALDH1A1ERN1HSD17B10MAPT | |
| SCHEMBL15225915 | 0.73 | ERN1 (0.52) | ALDH1A1ERN1TRIM24TYRTRIM33 | |
| SCHEMBL7921960 | 0.72 | ERN1 (0.59) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178578-B2 | Chemical compounds | THE UNIVERSITY OF MANCHESTER (GB) | 2012-05-15 | — | — | US | disclosed |
| US-20100016261-A1 | CHEMICAL COMPOUNDS | THE UNIVERSITY OF MANCHESTER (GB) | 2010-01-21 | — | — | US | disclosed |
| EP-2101755-A2 | POLYALKYLOXYDIBENZ (C,E) OXEPINE DERIVATIVES AS MEDICAMENTS | The University of Manchester (GB) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008075048-A2 | POLYALKYLOXYDIBENZ ( C, E) OXEPINE DERIVATIVES AS MEDICAMENTS | THE UNIVERSITY OF MANCHESTER (GB) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016261-A1 | CHEMICAL COMPOUNDS | CYP11B2, MPO, PIGO | KDM4E 3104/4885CYP1A2 49/4885CYP2D6 132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.