Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Phosphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.82 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.82 |
| ▸ | ACHE | P22303 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL27482461 | 0.97 | APOBEC3A (0.78) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Water SCHEMBL35582 | 0.97 | APOBEC3A (0.88) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Phosphine SCHEMBL27576303 | 0.97 | APOBEC3A (0.88) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Water SCHEMBL27482462 | 0.94 | APOBEC3A (0.82) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Water SCHEMBL28744902 | 0.94 | APOBEC3A (0.82) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| SCHEMBL12020269 | 0.94 | APOBEC3A (0.93) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| SCHEMBL147815 | 0.94 | APOBEC3A (0.93) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Methyl Alcohol SCHEMBL27917656 | 0.91 | APOBEC3A (0.78) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Bromide SCHEMBL238552 | 0.90 | APOBEC3A (0.88) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E | |
| Iodide SCHEMBL238393 | 0.90 | APOBEC3A (1.00) | APOBEC3AAPOBEC3GACHEALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1153798-C | Process for producing polycarbonate | 出光石油化学株式会社 | 2004-06-16 | — | — | CN | disclosed |
| CN-1469845-A | Process for recovering onium hydroxides from solutions containing onium compounds | ��������ķ������ | 2004-01-21 | — | — | CN | disclosed |