Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 2/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.37 |
| ▸ | STAMBP | O95630 | 1/20 | 0.37 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.37 |
| ▸ | XDH | P47989 | 2/20 | 0.36 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27415959 | 0.85 | HPGDS (0.41) | LRRK2HPGDSARSCN9AEGLN1 | |
| SCHEMBL27416291 | 0.84 | XDH (0.44) | XDH | |
| SCHEMBL31108446 | 0.82 | CYP11B2 (0.40) | LRRK2HPGDSXDHVNN1 | |
| SCHEMBL27415003 | 0.81 | EPHX2 (0.40) | POLBSCN9AEGLN1SCN5AVNN1 | |
| SCHEMBL27415994 | 0.81 | EPHX2 (0.42) | POLBEGLN2EGLN1 | |
| SCHEMBL17546403 | 0.79 | KDM4E (0.43) | LRRK2HPGDSPSMD14STAMBPCOPS5 | |
| SCHEMBL27465963 | 0.78 | LRRK2 (0.47) | LRRK2HPGDSPSMD14STAMBPCOPS5 | |
| SCHEMBL27415996 | 0.76 | MLYCD (0.37) | XDHSCN9ASCN5A | |
| SCHEMBL27415939 | 0.75 | EPHX2 (0.36) | POLBSCN9ASCN5A | |
| SCHEMBL27466143 | 0.74 | SCN9A (0.42) | POLBXDHSCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024129628-A1 | AURISTATIN LINKER-PAYLOADS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2024-06-20 | — | — | WO | disclosed |