Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 2/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | STAMBP | O95630 | 1/20 | 0.40 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20997619 | 0.83 | XDH (0.50) | SMN1; SMN2HPGDSLRRK2XDHEGLN1 | |
| SCHEMBL27465963 | 0.83 | LRRK2 (0.47) | KDM4ESMN1; SMN2HPGDSPSMD14STAMBP | |
| SCHEMBL29877405 | 0.81 | XDH (0.49) | KDM4ESMN1; SMN2XDH | |
| SCHEMBL2227107 | 0.81 | XDH (0.49) | KDM4ESMN1; SMN2XDH | |
| SCHEMBL16659359 | 0.81 | KDM4E (0.46) | KDM4ESMN1; SMN2XDHVNN1 | |
| SCHEMBL15582692 | 0.81 | GAA (0.49) | KDM4ESMN1; SMN2PSMD14CSF1RKCNH2 | |
| SCHEMBL28471033 | 0.80 | CYP11B2 (0.43) | KDM4ESMN1; SMN2HPGDSXDHAR | |
| SCHEMBL27417639 | 0.80 | SMN1; SMN2 (0.38) | KDM4ESMN1; SMN2XDHKCNH2VNN1 | |
| SCHEMBL27465877 | 0.79 | POLB (0.38) | HPGDSPSMD14STAMBPCOPS5LRRK2 | |
| SCHEMBL27417633 | 0.77 | KCNH2 (0.36) | KDM4ESMN1; SMN2XDHKCNH2VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160046597-A1 | RORC2 INHIBITORS AND METHODS OF USE THEREOF | PFIZER (US) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046597-A1 | RORC2 INHIBITORS AND METHODS OF USE THEREOF | RORC, RORB, RORA | KDM4E 1807/4885SMN1; SMN2 3833/4885HPGDS 686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.