Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27522830 | 0.91 | PTGS2 (0.46) | PTGS2SMN1; SMN2RAB9ALMNANPC1 | |
| SCHEMBL27486815 | 0.90 | PTGS2 (0.44) | PTGS2SMN1; SMN2LMNAITGB1ITGA4 | |
| SCHEMBL27489270 | 0.89 | PTGS2 (0.42) | PTGS2SMN1; SMN2RAB9ALMNANPC1 | |
| SCHEMBL27487526 | 0.89 | CYP1A2 (0.47) | PTGS2SMN1; SMN2RAB9AITGB1ITGA4 | |
| SCHEMBL27488603 | 0.89 | PTGS2 (0.42) | PTGS2SMN1; SMN2RAB9ALMNANPC1 | |
| SCHEMBL27489264 | 0.89 | PTGS2 (0.42) | PTGS2SMN1; SMN2RAB9ALMNANPC1 | |
| SCHEMBL27487893 | 0.89 | CYP1A2 (0.47) | PTGS2SMN1; SMN2RAB9AITGB1ITGA4 | |
| SCHEMBL27549351 | 0.88 | RAB9A (0.44) | PTGS2SMN1; SMN2RAB9ANPC1NPSR1 | |
| SCHEMBL27475808 | 0.87 | PTGS2 (0.42) | PTGS2SMN1; SMN2RAB9ALMNANPC1 | |
| SCHEMBL27487166 | 0.86 | PTGS2 (0.40) | PTGS2ITGB1ITGA4ITGB7PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1167687-C | Arylpyridazinones as prostaglandin endoperoxide H synthase biosynthesis inhibitors | ���Ͽع�����˾ | 2004-09-22 | — | — | CN | disclosed |
| CN-1277605-A | Arylpyridazinones as prostaglandin endoperoxide H synthase biosynthesis inhibitors | ABBOTT LAB (US) | 2000-12-20 | — | — | CN | disclosed |