SCHEMBL2746983

SCHEMBL2746983

O=C(O)c1ccccc1C(=O)OC#CC12CC3CC(CC(C3)C1)C2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.48
P2RX7 Q99572 1/20 0.41
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
ALDH1A1 P00352 3/20 0.40
ALOX15 P16050 1/20 0.40
EPHX2 P34913 4/20 0.39
EPHX1 P07099 2/20 0.39
HIF1A Q16665 1/20 0.38
EPAS1 Q99814 1/20 0.38
MAPT P10636 1/20 0.38
HPGD P15428 1/20 0.38
TSHR P16473 1/20 0.38
ALOX12 P18054 1/20 0.38
HTT P42858 1/20 0.38
ATM Q13315 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2746981 0.94 KDM4E (0.42) KDM4EP2RX7ALDH1A1EPHX2EPHX1
SCHEMBL2710679 0.75 KDM4E (0.44) KDM4EP2RX7ALDH1A1ALOX15EPHX2
Hydrochloric Acid SCHEMBL5000607 0.74 KDM4E (0.43) KDM4EP2RX7ALDH1A1ALOX15EPHX2
Phthalic Acid SCHEMBL28793332 0.72 ALDH1A1 (0.70) KDM4EP2RX7ALDH1A1ALOX15MAPT
SCHEMBL2708211 0.70 KDM4E (0.41) KDM4EP2RX7ALDH1A1EPHX2EPHX1
SCHEMBL2710316 0.70 HNF4A (0.39) KDM4EP2RX7EPHX2EPHX1HIF1A
SCHEMBL8134445 0.68 CYP19A1 (0.46) KDM4EP2RX7ALDH1A1MAPTHPGD
SCHEMBL2746516 0.68 ALDH1A1 (0.52) KDM4EALDH1A1ALOX15MAPTHPGD
SCHEMBL2747010 0.68 ALDH1A1 (0.56) KDM4ECYP2C9TDP1ALDH1A1ALOX15
SCHEMBL5475249 0.67 KDM4E (0.53) KDM4EP2RX7CYP3A4ALDH1A1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8178631-B2 Resin composition, varnish, resin film and semiconductor device SUMITOMO BAKELITE COMPANY, LTD. (JP) 2012-05-15 US disclosed
US-20090214860-A1 Resin Composition, Varnish, Resin Film and Semiconductor Device SUMITOMO BAKELITE COMPANY, LTD. (JP) 2009-08-27 US disclosed
EP-1953181-A1 RESIN COMPOSITION, VARNISH, RESIN FILM AND SEMICONDUCTOR DEVICE Sumitomo Bakelite Company, Ltd. (JP) 2008-08-06 EP disclosed