Phorbol

Phorbol

SCHEMBL27478115

CC1=C[C@H]2[C@]3(O)[C@H](C)[C@@H](O)[C@@]4(O)[C@H]([C@@H]3C=C(CO)C[C@@]2(O)C1=O)C4(C)C.CCCCCCCCCCCCCC(=O)CC(=O)O

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRKCA P17252 5/20 0.60
▸ PRKCG P05129 5/20 0.60
▸ PRKD3 O94806 4/20 0.60
▸ PRKCB P05771 4/20 0.60
▸ PRKCH P24723 4/20 0.60
▸ PRKCI P41743 4/20 0.60
▸ PRKCE Q02156 4/20 0.60
▸ PRKCQ Q04759 4/20 0.60
▸ PRKCZ Q05513 4/20 0.60
▸ PRKCD Q05655 4/20 0.60
▸ PRKD1 Q15139 4/20 0.60
▸ USP2 O75604 2/20 0.60
▸ TP53 P04637 2/20 0.60
▸ KDM4E B2RXH2 1/20 0.60
▸ ALDH1A1 P00352 1/20 0.60
▸ SMN1; SMN2 Q16637 1/20 0.60
▸ CYP3A4 P08684 1/20 0.60
▸ CYP2C9 P11712 1/20 0.60
▸ TSHR P16473 1/20 0.60
▸ NFKB1 P19838 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phorbol SCHEMBL7615331 0.94 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27419386 0.94 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL28866474 0.94 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL64353 0.94 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL22973790 0.94 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27299282 0.93 PRKCA (0.63) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27333666 0.91 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27579226 0.89 PRKCA (0.67) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL7566989 0.89 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL28306320 0.89 PRKCA (0.63) PRKCAPRKCGPRKD3PRKCBPRKCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113686830-B Batch semi-channel function level detection method based on fluorescent dye uptake 中国环境科学研究院 2022-05-20 — — CN claimed
CN-113686830-A Batch semi-channel function level detection method based on fluorescent dye uptake 中国环境科学研究院 2021-11-23 — — CN claimed
CN-119997962-A Improving efficacy and sustained response of immunotherapy 凯德药业股份有限公司 2025-05-13 — — CN disclosed
CN-119343444-A Method for preparing lymphocytes for cell therapy 凯德药业股份有限公司 2025-01-21 — — CN disclosed
CN-116997564-A Improving immune cell function 凯德药业股份有限公司 2023-11-03 — — CN disclosed
CN-116113689-A Improving immune cell function 凯德药业股份有限公司 2023-05-12 — — CN disclosed
CN-115485293-A Chimeric antigen receptor for HER2 and methods of use thereof 埃克苏马生物技术公司 2022-12-16 — — CN disclosed
CN-114796474-A Vaccine compositions with improved stability and immunogenicity 诺瓦瓦克斯股份有限公司 2022-07-29 — — CN disclosed
CN-114786697-A Diterpenoids acting on Protein Kinase C (PKC) K-GEN股份有限公司 2022-07-22 — — CN disclosed
CN-114699519-A Vaccine compositions with improved stability and immunogenicity 诺瓦瓦克斯股份有限公司 2022-07-05 — — CN disclosed
CN-114667285-A Antiviral pyrazolopyridinone compounds 诺华股份有限公司 2022-06-24 — — CN disclosed
CN-101039689-B Topical compositions and methods for epithelial-related disorders SIGNUM BIOSCIENCES INC 2013-01-30 — — CN disclosed
CN-101641080-A Use of chroman-4-one derivatives MERCK PATENT GMBH DE 2010-02-03 — — CN disclosed
CN-101277614-A Methods for bone treatment by modulating an arachidonic acid metabolic or signaling pathway ACCELALOX INC (US) 2008-10-01 — — CN disclosed
CN-101039689-A Topical compositions and methods for epithelial-related disorders SIGNUM BIOSCIENCES INC (US) 2007-09-19 — — CN disclosed
CN-1980687-A Albumin fusion proteins HUMAN GENOME SCIENCES INC (US) 2007-06-13 — — CN disclosed
CN-1210029-C Treating for skin disease BTG INT LTD (GB) 2005-07-13 — — CN disclosed
CN-1158073-C Application of protein kinase C inhibitor in preparation of medicine — 2004-07-21 — — CN disclosed
CN-1330545-A Treating for skin disease BTG INT LTD (GB) 2002-01-09 — — CN disclosed
CN-1222850-A Therapeutic treatment for VEGF related occular diseases LILLY CO ELI (US) 1999-07-14 — — CN disclosed
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