Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8740250 | 0.82 | NFE2L2 (0.43) | NFE2L2NR1H3NR1H2KDM4EGAA | |
| SCHEMBL30839044 | 0.75 | SLC22A12 (0.36) | NFE2L2NR1H3NR1H2RXRASLC22A12 | |
| Hydrochloric Acid SCHEMBL27460502 | 0.74 | ADRA2A (0.40) | RXRAALDH1A1SLC22A12LMNAMAPT | |
| SCHEMBL28231669 | 0.73 | MEN1 (0.43) | NR1H3NR1H2KDM4EALDH1A1LMNA | |
| SCHEMBL8669834 | 0.73 | BRAF (0.39) | NFE2L2NR1H3NR1H2RXRAKDM4E | |
| SCHEMBL29183881 | 0.71 | MCL1 (0.42) | NR1H3NR1H2SLC22A12MEN1CYP1A2 | |
| Hydrochloric Acid SCHEMBL27456687 | 0.70 | SLC6A4 (0.32) | KDM4EALDH1A1MEN1CYP1A2CYP3A4 | |
| SCHEMBL31172692 | 0.68 | NFE2L2 (0.42) | NFE2L2GAASLC22A12KMT2A | |
| SCHEMBL3598103 | 0.68 | NFE2L2 (0.42) | NFE2L2GAASLC22A12KMT2A | |
| SCHEMBL6630905 | 0.68 | NFE2L2 (0.42) | NFE2L2GAASLC22A12LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1128817-C | Solid catalyst for olefin polymerization and process for producing olefin polymer using the same | MARUZEN PETROCHEM CO LTD (JP) | 2003-11-26 | — | — | CN | disclosed |