Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | PNLIP | P16233 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27486254 | 0.90 | SMN1; SMN2 (0.53) | KDRSMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL27467102 | 0.85 | SMN1; SMN2 (0.54) | KDRSMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL27485595 | 0.85 | KDR (0.60) | KDRSMN1; SMN2MAPTFLT1NPC1 | |
| SCHEMBL27486256 | 0.84 | KDR (0.57) | KDRSMN1; SMN2MAPTLMNAALDH1A1 | |
| SCHEMBL27609433 | 0.84 | ALDH1A1 (0.52) | KDRSMN1; SMN2MAPTFLT1HTT | |
| SCHEMBL27485244 | 0.83 | ALDH1A1 (0.52) | KDRSMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL27485596 | 0.80 | KCNK3 (0.49) | KDRSMN1; SMN2MAPTFLT1HTT | |
| SCHEMBL27548636 | 0.79 | NAMPT (0.56) | KDRSMN1; SMN2MAPTFLT1HTT | |
| SCHEMBL27468045 | 0.79 | KDR (0.44) | KDRSMN1; SMN2MAPTFLT1HTT | |
| SCHEMBL5674964 | 0.78 | PNLIP (0.70) | SMN1; SMN2PNLIPLMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1331680-A | N-aryl (thio) anthranilic acid amide derivatives, their prepn. and their use as VEGF receptor tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2002-01-16 | — | — | CN | claimed |
| CN-1152014-C | N-aryl (thio) anthranilic acid amide derivatives, their prepn. and their use as VEGF receptor tyrosine kinase inhibitors | ��˹��ŵ�� | 2004-06-02 | — | — | CN | disclosed |
| CN-1331680-A | N-aryl (thio) anthranilic acid amide derivatives, their prepn. and their use as VEGF receptor tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2002-01-16 | — | — | CN | disclosed |