Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 4/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | TPO | P07202 | 1/20 | 0.31 |
| ▸ | EPX | P11678 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28325986 | 0.86 | HCAR3 (0.34) | DPP4AKR1B1ARHCAR3KDM4E | |
| SCHEMBL28327134 | 0.83 | AKR1B1 (0.32) | DPP4AKR1B1ARHCAR3CYP3A4 | |
| SCHEMBL28325982 | 0.83 | HCAR3 (0.34) | DPP4AKR1B1ARHCAR3SLC6A2 | |
| SCHEMBL28327127 | 0.82 | AKR1B1 (0.36) | DPP4AKR1B1ARKDM4EALDH1A1 | |
| SCHEMBL27977725 | 0.80 | AKR1B1 (0.33) | DPP4AKR1B1ARALDH1A1IDO1 | |
| SCHEMBL28113663 | 0.77 | AKR1B1 (0.38) | DPP4AKR1B1MPOAKT1 | |
| SCHEMBL28113597 | 0.74 | AKR1B1 (0.36) | DPP4AKR1B1AKT1 | |
| SCHEMBL27944384 | 0.74 | GLS (0.32) | — | |
| SCHEMBL2928229 | 0.73 | MPO (0.47) | AKR1B1MPOARHCAR3KDM4E | |
| SCHEMBL27808924 | 0.72 | ROCK2 (0.36) | DPP4PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107223125-B | SGC stimulant | 赛科理音医疗有限公司 | 2019-09-27 | — | — | CN | disclosed |
| CN-105503867-B | The method for being used to prepare the fluoro- 1H- pyrazolo-pyridines of substituted 5- | 阿德弗里奥药品有限责任公司 | 2019-01-11 | — | — | CN | disclosed |
| CN-104159898-B | Process for preparing substituted 5-fluoro-1H-pyrazolopyridines | 阿德弗里奥药品有限责任公司 | 2017-01-18 | — | — | CN | disclosed |
| CN-105503867-A | Method for producing substituted 5-fluoro-lH-pyrazolopyridines | ADVERIO PHARMA GMBH | 2016-04-20 | — | — | CN | disclosed |
| CN-104159898-A | Process for preparing substituted 5-fluoro-1H-pyrazolopyridines | Bayer Pharma AG | 2014-11-19 | — | — | CN | disclosed |
| CN-1165536-C | Substituted pyrazole derivatives condensed with six-membered heterocyclic rings | — | 2004-09-08 | — | — | CN | disclosed |