SCHEMBL27490282

SCHEMBL27490282

CCc1ccc(Cc2[c]cccc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.44
CYP2A6 P11509 2/20 0.36
CYP1A2 P05177 1/20 0.36
NPC1 O15118 3/20 0.35
RAB9A P51151 3/20 0.35
KDM4E B2RXH2 1/20 0.35
TAAR1 Q96RJ0 1/20 0.34
PLK1 P53350 1/20 0.33
MGLL Q99685 1/20 0.33
LPL P06858 1/20 0.33
LIPG Q9Y5X9 1/20 0.33
ALDH1A1 P00352 3/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32
MAPK1 P28482 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CALM1 P0DP23 1/20 0.32
KIF11 P52732 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6353303 0.84 IDO1 (0.37) TP53CYP2A6CYP1A2NPC1RAB9A
SCHEMBL79754 0.83 CALM1 (0.50) TP53KDM4EALDH1A1LMNAMAPT
SCHEMBL7785326 0.80 NQO1 (0.47) TP53CYP1A2KDM4EALDH1A1SMN1; SMN2
SCHEMBL6270990 0.80 SLC6A4 (0.42) RAB9AALDH1A1SMN1; SMN2MAPK1
SCHEMBL4390802 0.80 APP (0.37) CALM1
SCHEMBL8791282 0.80 ESR1 (0.50) CYP1A2KDM4ETAAR1ALDH1A1LMNA
SCHEMBL1531966 0.80 SIGMAR1 (0.37) KDM4ETAAR1ALDH1A1LMNAMAPT
SCHEMBL17956849 0.80 CYP3A4 (0.50) NPC1RAB9AALDH1A1SMN1; SMN2LMNA
SCHEMBL1531987 0.80 IDO1 (0.37) KDM4ETAAR1ALDH1A1LMNAMAPT
SCHEMBL8939729 0.80 TAAR1 (0.43) CYP1A2RAB9ATAAR1MGLLALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114450011-A Compositions and methods for treating metabolic disorders 阿沃林特有限公司 2022-05-06 CN disclosed
CN-1177857-C Glucopyranosyloxy benzylbenzene derivatives, medicinal compositions containing the same and intermediates for the prepararation of the derivatives ����ҩƷ��ҵ��ʽ���� 2004-12-01 CN disclosed
CN-1418219-A Glucopyranosyloxy benzylbenzene derivatives, medicinal compositions containing the same and intermediates for the prepararation of the derivatives KISSEI PHARMACEUTICAL (JP) 2003-05-14 CN disclosed